FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980587707> ?p ?o ?g. }

• W1980587707 endingPage "6243" @default.
• W1980587707 startingPage "6239" @default.
• W1980587707 abstract "We have investigated the mitogenic effect of three mutant forms of human insulin on insulin-producing beta cells of the developing pancreas. We examined transgenic embryonic and adult mice expressing (i) human [AspB10]-proinsulin/insulin ([AspB10]ProIN/IN), produced by replacement of histidine by aspartic acid at position 10 of the B chain and characterized by an increased affinity for the insulin receptor; (ii) human [LeuA3]insulin, produced by the substitution of leucine for valine in position 3 of the A chain, which exhibits decreased receptor binding affinity; and (iii) human [LeuA3, AspB10]insulin double mutation. During development, beta cells of AspB10 embryos were twice as abundant and had a 3 times higher rate of proliferation compared with beta cells of littermate controls. The mitogenic effect of [AspB10]ProIN/IN was specific for embryonic beta cells because the rate of proliferation of beta cells of adults and of glucagon (alpha) cells and adrenal chromaffin cells of embryos was similar in AspB10 mice and controls. In contrast to AspB10 embryos, the number of beta cells in the LeuA3 and double mutant lines was similar to the number in controls. These findings indicate that the [AspB10]ProIN/IN analog increased the rate of fetal beta-cell proliferation. The mechanism or mechanisms that mediate this mitogenic effect remain to be determined." @default.
• W1980587707 created "2016-06-24" @default.
• W1980587707 creator A5000822072 @default.
• W1980587707 creator A5025145880 @default.
• W1980587707 creator A5026523066 @default.
• W1980587707 creator A5044891277 @default.
• W1980587707 creator A5080725730 @default.
• W1980587707 creator A5081847362 @default.
• W1980587707 creator A5088193508 @default.
• W1980587707 date "1995-07-03" @default.
• W1980587707 modified "2023-10-16" @default.
• W1980587707 title "A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cells." @default.
• W1980587707 cites W1509427422 @default.
• W1980587707 cites W1782483762 @default.
• W1980587707 cites W1985829064 @default.
• W1980587707 cites W1990939392 @default.
• W1980587707 cites W1993672117 @default.
• W1980587707 cites W1995165138 @default.
• W1980587707 cites W2003196630 @default.
• W1980587707 cites W2006485431 @default.
• W1980587707 cites W2014906581 @default.
• W1980587707 cites W2016682279 @default.
• W1980587707 cites W2017949036 @default.
• W1980587707 cites W2020821717 @default.
• W1980587707 cites W2029772086 @default.
• W1980587707 cites W2033482946 @default.
• W1980587707 cites W2054668289 @default.
• W1980587707 cites W2059810045 @default.
• W1980587707 cites W2084732252 @default.
• W1980587707 cites W2084918744 @default.
• W1980587707 cites W2092964123 @default.
• W1980587707 cites W2104168724 @default.
• W1980587707 cites W2115073960 @default.
• W1980587707 cites W2125398472 @default.
• W1980587707 cites W2133930018 @default.
• W1980587707 cites W2158146678 @default.
• W1980587707 cites W2164033269 @default.
• W1980587707 cites W2166421062 @default.
• W1980587707 cites W2409094784 @default.
• W1980587707 cites W2887036954 @default.
• W1980587707 doi "https://doi.org/10.1073/pnas.92.14.6239" @default.
• W1980587707 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/41493" @default.
• W1980587707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7603977" @default.
• W1980587707 hasPublicationYear "1995" @default.
• W1980587707 type Work @default.
• W1980587707 sameAs 1980587707 @default.
• W1980587707 citedByCount "14" @default.
• W1980587707 countsByYear W19805877072013 @default.
• W1980587707 crossrefType "journal-article" @default.
• W1980587707 hasAuthorship W1980587707A5000822072 @default.
• W1980587707 hasAuthorship W1980587707A5025145880 @default.
• W1980587707 hasAuthorship W1980587707A5026523066 @default.
• W1980587707 hasAuthorship W1980587707A5044891277 @default.
• W1980587707 hasAuthorship W1980587707A5080725730 @default.
• W1980587707 hasAuthorship W1980587707A5081847362 @default.
• W1980587707 hasAuthorship W1980587707A5088193508 @default.
• W1980587707 hasBestOaLocation W19805877071 @default.
• W1980587707 hasConcept C104317684 @default.
• W1980587707 hasConcept C126322002 @default.
• W1980587707 hasConcept C134018914 @default.
• W1980587707 hasConcept C145103041 @default.
• W1980587707 hasConcept C153911025 @default.
• W1980587707 hasConcept C165220095 @default.
• W1980587707 hasConcept C170493617 @default.
• W1980587707 hasConcept C196843134 @default.
• W1980587707 hasConcept C199360897 @default.
• W1980587707 hasConcept C2776174256 @default.
• W1980587707 hasConcept C2776828364 @default.
• W1980587707 hasConcept C2777573094 @default.
• W1980587707 hasConcept C2778563252 @default.
• W1980587707 hasConcept C2779306644 @default.
• W1980587707 hasConcept C41008148 @default.
• W1980587707 hasConcept C515207424 @default.
• W1980587707 hasConcept C54355233 @default.
• W1980587707 hasConcept C55493867 @default.
• W1980587707 hasConcept C71924100 @default.
• W1980587707 hasConcept C81885089 @default.
• W1980587707 hasConcept C86803240 @default.
• W1980587707 hasConcept C90061646 @default.
• W1980587707 hasConcept C95444343 @default.
• W1980587707 hasConceptScore W1980587707C104317684 @default.
• W1980587707 hasConceptScore W1980587707C126322002 @default.
• W1980587707 hasConceptScore W1980587707C134018914 @default.
• W1980587707 hasConceptScore W1980587707C145103041 @default.
• W1980587707 hasConceptScore W1980587707C153911025 @default.
• W1980587707 hasConceptScore W1980587707C165220095 @default.
• W1980587707 hasConceptScore W1980587707C170493617 @default.
• W1980587707 hasConceptScore W1980587707C196843134 @default.
• W1980587707 hasConceptScore W1980587707C199360897 @default.
• W1980587707 hasConceptScore W1980587707C2776174256 @default.
• W1980587707 hasConceptScore W1980587707C2776828364 @default.
• W1980587707 hasConceptScore W1980587707C2777573094 @default.
• W1980587707 hasConceptScore W1980587707C2778563252 @default.
• W1980587707 hasConceptScore W1980587707C2779306644 @default.
• W1980587707 hasConceptScore W1980587707C41008148 @default.
• W1980587707 hasConceptScore W1980587707C515207424 @default.
• W1980587707 hasConceptScore W1980587707C54355233 @default.
• W1980587707 hasConceptScore W1980587707C55493867 @default.

• next