FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980589318> ?p ?o ?g. }

• W1980589318 endingPage "915" @default.
• W1980589318 startingPage "910" @default.
• W1980589318 abstract "HaCat cells, a human keratinocyte line, are commonly utilised as an in vitro cell model for toxicity testing and the discernment of processes of chemically induced skin carcinogenesis. Here, as part of an ongoing program of carcinogenesis research, we tested the genomic transcriptional response of two keratinocyte cell lines HaCat (human) and Pam212 (mouse) to 12-O-tetradecanoylphorbol 13-acetate (TPA), one of the most studied skin carcinoma promoting agents, and compared this with the response in primary keratinocytes. Differences in the genomic response profile indicated an insufficiency in the MEK/ERK pathway signalling in HaCat but not Pam212 cells compared to primary keratinocytes. TPA can also activate NFκB and so we tested whether this was also deficient in the HaCat cells using TNFα which signals directly to NFκB. By this method NFκB was found to be equally active in both HaCat and Pam212 cells. Analysis of ERK phosphorylation showed that while TPA mediated ERK phosphorylation occurred in both cell lines it was more robust and difficult to inhibit in Pam212 cells suggesting that there may be an insufficiency in this step in HaCat cells leading to a reduced response. Overall these data indicate that caution should be employed when using HaCat cells as an in vitro skin model for biochemical research or toxicological evaluation." @default.
• W1980589318 created "2016-06-24" @default.
• W1980589318 creator A5004567313 @default.
• W1980589318 creator A5056381889 @default.
• W1980589318 creator A5062535075 @default.
• W1980589318 creator A5078090457 @default.
• W1980589318 date "2010-04-01" @default.
• W1980589318 modified "2023-10-18" @default.
• W1980589318 title "Defective TPA signalling compromises HaCat cells as a human in vitro skin carcinogenesis model" @default.
• W1980589318 cites W1569152804 @default.
• W1980589318 cites W1971532666 @default.
• W1980589318 cites W1983546164 @default.
• W1980589318 cites W1992216304 @default.
• W1980589318 cites W2000131007 @default.
• W1980589318 cites W2000618536 @default.
• W1980589318 cites W2001230322 @default.
• W1980589318 cites W2013696877 @default.
• W1980589318 cites W2020068174 @default.
• W1980589318 cites W2029742330 @default.
• W1980589318 cites W2030583577 @default.
• W1980589318 cites W2036670951 @default.
• W1980589318 cites W2037994279 @default.
• W1980589318 cites W2038085058 @default.
• W1980589318 cites W2041835207 @default.
• W1980589318 cites W2047051739 @default.
• W1980589318 cites W2050202520 @default.
• W1980589318 cites W2055569826 @default.
• W1980589318 cites W2066506893 @default.
• W1980589318 cites W2083283822 @default.
• W1980589318 cites W2086111134 @default.
• W1980589318 cites W2088359708 @default.
• W1980589318 cites W2088481283 @default.
• W1980589318 cites W2095009290 @default.
• W1980589318 cites W2095259974 @default.
• W1980589318 cites W2102512302 @default.
• W1980589318 cites W2116688192 @default.
• W1980589318 cites W2143464311 @default.
• W1980589318 cites W2163362161 @default.
• W1980589318 cites W2325361549 @default.
• W1980589318 cites W4236186928 @default.
• W1980589318 doi "https://doi.org/10.1016/j.tiv.2009.11.017" @default.
• W1980589318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19945525" @default.
• W1980589318 hasPublicationYear "2010" @default.
• W1980589318 type Work @default.
• W1980589318 sameAs 1980589318 @default.
• W1980589318 citedByCount "12" @default.
• W1980589318 countsByYear W19805893182012 @default.
• W1980589318 countsByYear W19805893182013 @default.
• W1980589318 countsByYear W19805893182014 @default.
• W1980589318 countsByYear W19805893182017 @default.
• W1980589318 countsByYear W19805893182018 @default.
• W1980589318 countsByYear W19805893182019 @default.
• W1980589318 countsByYear W19805893182020 @default.
• W1980589318 countsByYear W19805893182021 @default.
• W1980589318 countsByYear W19805893182022 @default.
• W1980589318 crossrefType "journal-article" @default.
• W1980589318 hasAuthorship W1980589318A5004567313 @default.
• W1980589318 hasAuthorship W1980589318A5056381889 @default.
• W1980589318 hasAuthorship W1980589318A5062535075 @default.
• W1980589318 hasAuthorship W1980589318A5078090457 @default.
• W1980589318 hasConcept C104317684 @default.
• W1980589318 hasConcept C118995209 @default.
• W1980589318 hasConcept C11960822 @default.
• W1980589318 hasConcept C1491633281 @default.
• W1980589318 hasConcept C185592680 @default.
• W1980589318 hasConcept C202751555 @default.
• W1980589318 hasConcept C2777074287 @default.
• W1980589318 hasConcept C502942594 @default.
• W1980589318 hasConcept C54355233 @default.
• W1980589318 hasConcept C55493867 @default.
• W1980589318 hasConcept C555283112 @default.
• W1980589318 hasConcept C57074206 @default.
• W1980589318 hasConcept C81885089 @default.
• W1980589318 hasConcept C86803240 @default.
• W1980589318 hasConcept C95444343 @default.
• W1980589318 hasConceptScore W1980589318C104317684 @default.
• W1980589318 hasConceptScore W1980589318C118995209 @default.
• W1980589318 hasConceptScore W1980589318C11960822 @default.
• W1980589318 hasConceptScore W1980589318C1491633281 @default.
• W1980589318 hasConceptScore W1980589318C185592680 @default.
• W1980589318 hasConceptScore W1980589318C202751555 @default.
• W1980589318 hasConceptScore W1980589318C2777074287 @default.
• W1980589318 hasConceptScore W1980589318C502942594 @default.
• W1980589318 hasConceptScore W1980589318C54355233 @default.
• W1980589318 hasConceptScore W1980589318C55493867 @default.
• W1980589318 hasConceptScore W1980589318C555283112 @default.
• W1980589318 hasConceptScore W1980589318C57074206 @default.
• W1980589318 hasConceptScore W1980589318C81885089 @default.
• W1980589318 hasConceptScore W1980589318C86803240 @default.
• W1980589318 hasConceptScore W1980589318C95444343 @default.
• W1980589318 hasIssue "3" @default.
• W1980589318 hasLocation W19805893181 @default.
• W1980589318 hasLocation W19805893182 @default.
• W1980589318 hasOpenAccess W1980589318 @default.
• W1980589318 hasPrimaryLocation W19805893181 @default.
• W1980589318 hasRelatedWork W1990242042 @default.
• W1980589318 hasRelatedWork W2020815139 @default.
• W1980589318 hasRelatedWork W2028732613 @default.

• next