Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980594100> ?p ?o ?g. }
- W1980594100 abstract "Accumulating evidence suggests that urokinase plasminogen activator (uPA) is involved in vascular remodeling and lumen stenosis after angioplasty and stenting. We have shown previously that increased uPA expression greatly promotes neointima formation and inward arterial remodeling after balloon injury. To evaluate the role of inflammation in early mechanisms responsible for inward arterial remodeling induced by uPA and elucidate the mechanisms of remodeling, we characterized changes in the expression profiles of 8,799 genes in injured rat carotid arteries 1 and 4 days after recombinant uPA treatment compared to vehicle. We used a standard model of the balloon catheter injury of the rat carotid followed by periadventitial application to the injured vessel of either uPA dissolved in Pluronic gel, or plain gel. Vessels were harvested and analyzed by immunohistochemistry, morphometry, microarray gene expression profiling and quantitative RT-PCR. Periadventitial application of uPA significantly reduced lumen size and vessel area encompassed by the external elastic lamina at both 1 and 4 days after treatment. Inflammatory cells accumulated in the arterial adventitia at both 1 and 4 days after uPA treatment. On" @default.
- W1980594100 created "2016-06-24" @default.
- W1980594100 creator A5003632963 @default.
- W1980594100 creator A5007874845 @default.
- W1980594100 creator A5035482823 @default.
- W1980594100 creator A5048576669 @default.
- W1980594100 creator A5062860224 @default.
- W1980594100 creator A5086432973 @default.
- W1980594100 date "2008-05-01" @default.
- W1980594100 modified "2023-09-28" @default.
- W1980594100 title "OLIGONUCLEOTIDE MICROARRAYS REVEAL REGULATED GENES RELATED TO INWARD ARTERIAL REMODELING INDUCED BY UROKINASE PLASMINOGEN ACTIVATOR" @default.
- W1980594100 cites W1708068686 @default.
- W1980594100 cites W1786019949 @default.
- W1980594100 cites W1874647745 @default.
- W1980594100 cites W1945743004 @default.
- W1980594100 cites W1963927454 @default.
- W1980594100 cites W1964505481 @default.
- W1980594100 cites W1977673096 @default.
- W1980594100 cites W1983039493 @default.
- W1980594100 cites W1987134694 @default.
- W1980594100 cites W1987700050 @default.
- W1980594100 cites W1993209978 @default.
- W1980594100 cites W2001409596 @default.
- W1980594100 cites W2004476148 @default.
- W1980594100 cites W2008419170 @default.
- W1980594100 cites W2020780927 @default.
- W1980594100 cites W2033341544 @default.
- W1980594100 cites W2034226927 @default.
- W1980594100 cites W2036467841 @default.
- W1980594100 cites W2036722319 @default.
- W1980594100 cites W2038027577 @default.
- W1980594100 cites W2045208662 @default.
- W1980594100 cites W2060341674 @default.
- W1980594100 cites W2068981042 @default.
- W1980594100 cites W2085058944 @default.
- W1980594100 cites W2089840669 @default.
- W1980594100 cites W2091557419 @default.
- W1980594100 cites W2093959898 @default.
- W1980594100 cites W2105042864 @default.
- W1980594100 cites W2107163773 @default.
- W1980594100 cites W2107693178 @default.
- W1980594100 cites W2114371777 @default.
- W1980594100 cites W2117188544 @default.
- W1980594100 cites W2123294765 @default.
- W1980594100 cites W2126524259 @default.
- W1980594100 cites W2134665522 @default.
- W1980594100 cites W2137287545 @default.
- W1980594100 cites W2139277868 @default.
- W1980594100 cites W2155199896 @default.
- W1980594100 cites W2166160060 @default.
- W1980594100 cites W2299231629 @default.
- W1980594100 cites W2322745866 @default.
- W1980594100 cites W2324476825 @default.
- W1980594100 cites W2411289095 @default.
- W1980594100 doi "https://doi.org/10.1016/s1567-5688(08)70127-2" @default.
- W1980594100 hasPublicationYear "2008" @default.
- W1980594100 type Work @default.
- W1980594100 sameAs 1980594100 @default.
- W1980594100 citedByCount "0" @default.
- W1980594100 crossrefType "journal-article" @default.
- W1980594100 hasAuthorship W1980594100A5003632963 @default.
- W1980594100 hasAuthorship W1980594100A5007874845 @default.
- W1980594100 hasAuthorship W1980594100A5035482823 @default.
- W1980594100 hasAuthorship W1980594100A5048576669 @default.
- W1980594100 hasAuthorship W1980594100A5062860224 @default.
- W1980594100 hasAuthorship W1980594100A5086432973 @default.
- W1980594100 hasConcept C126322002 @default.
- W1980594100 hasConcept C131631996 @default.
- W1980594100 hasConcept C142724271 @default.
- W1980594100 hasConcept C2776205367 @default.
- W1980594100 hasConcept C2776716733 @default.
- W1980594100 hasConcept C2776820930 @default.
- W1980594100 hasConcept C2776914184 @default.
- W1980594100 hasConcept C2777339539 @default.
- W1980594100 hasConcept C2778283817 @default.
- W1980594100 hasConcept C2778583881 @default.
- W1980594100 hasConcept C2779679481 @default.
- W1980594100 hasConcept C2780326628 @default.
- W1980594100 hasConcept C71924100 @default.
- W1980594100 hasConceptScore W1980594100C126322002 @default.
- W1980594100 hasConceptScore W1980594100C131631996 @default.
- W1980594100 hasConceptScore W1980594100C142724271 @default.
- W1980594100 hasConceptScore W1980594100C2776205367 @default.
- W1980594100 hasConceptScore W1980594100C2776716733 @default.
- W1980594100 hasConceptScore W1980594100C2776820930 @default.
- W1980594100 hasConceptScore W1980594100C2776914184 @default.
- W1980594100 hasConceptScore W1980594100C2777339539 @default.
- W1980594100 hasConceptScore W1980594100C2778283817 @default.
- W1980594100 hasConceptScore W1980594100C2778583881 @default.
- W1980594100 hasConceptScore W1980594100C2779679481 @default.
- W1980594100 hasConceptScore W1980594100C2780326628 @default.
- W1980594100 hasConceptScore W1980594100C71924100 @default.
- W1980594100 hasLocation W19805941001 @default.
- W1980594100 hasOpenAccess W1980594100 @default.
- W1980594100 hasPrimaryLocation W19805941001 @default.
- W1980594100 hasRelatedWork W1972296124 @default.
- W1980594100 hasRelatedWork W1980848458 @default.
- W1980594100 hasRelatedWork W1987134694 @default.
- W1980594100 hasRelatedWork W1988169167 @default.
- W1980594100 hasRelatedWork W2014694207 @default.