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- W1980594873 endingPage "232" @default.
- W1980594873 startingPage "221" @default.
- W1980594873 abstract "Drug development from early discovery to late stage commercialization is a long arduous process where a number of factors are taken into consideration when deciding on a particular immunoglobulin isotype for a therapeutic purpose. There are no general rules for which isotype is selected; however, prior experiences, effector function and the specific therapy targeted, as well as extensive testing early in development help in paring the number of candidates. Over 20 monoclonal antibodies are FDA-approved, and most are IgG1 isotype, although a number of non-IgG1 molecules have been approved recently and the number in development is on the rise. Analytical techniques that examine the physicochemical properties of a molecule provide vital information on the stability and efficacy of candidate antibody therapeutics, but most of these studies are conducted using standard buffers and under well defined storage conditions. It has recently become apparent that analysis of antibody therapeutics recovered after circulation in blood show altered physicochemical characteristics, and in many instances therapeutic molecules recovered from serum show lower potency. This review examines some of these studies, with a focus on the physicochemical changes observed in the molecules. Technologies that can facilitate rapid screening of candidate antibody therapeutics directly from blood are highlighted. The facts indicate that antibody therapeutic development programs must incorporate understanding of the basic biology of the isotype and its stability in serum, which is the intended environment of the therapeutic." @default.
- W1980594873 created "2016-06-24" @default.
- W1980594873 creator A5075115675 @default.
- W1980594873 date "2010-05-01" @default.
- W1980594873 modified "2023-10-07" @default.
- W1980594873 title "Stability of IgG isotypes in serum" @default.
- W1980594873 cites W122291305 @default.
- W1980594873 cites W1493053489 @default.
- W1980594873 cites W1520693665 @default.
- W1980594873 cites W1529809181 @default.
- W1980594873 cites W1544644780 @default.
- W1980594873 cites W1550340517 @default.
- W1980594873 cites W1594992446 @default.
- W1980594873 cites W1600956528 @default.
- W1980594873 cites W1657453984 @default.
- W1980594873 cites W1839631757 @default.
- W1980594873 cites W1846037014 @default.
- W1980594873 cites W1895993106 @default.
- W1980594873 cites W1954829482 @default.
- W1980594873 cites W1965933027 @default.
- W1980594873 cites W1967265624 @default.
- W1980594873 cites W1968037422 @default.
- W1980594873 cites W1968614040 @default.
- W1980594873 cites W1969317566 @default.
- W1980594873 cites W1972879829 @default.
- W1980594873 cites W1974159983 @default.
- W1980594873 cites W1976394313 @default.
- W1980594873 cites W1976681671 @default.
- W1980594873 cites W1976837580 @default.
- W1980594873 cites W1979626824 @default.
- W1980594873 cites W1981731904 @default.
- W1980594873 cites W1982429319 @default.
- W1980594873 cites W1983519034 @default.
- W1980594873 cites W1985102822 @default.
- W1980594873 cites W1985947600 @default.
- W1980594873 cites W1986864699 @default.
- W1980594873 cites W1994316927 @default.
- W1980594873 cites W1998172822 @default.
- W1980594873 cites W1998744147 @default.
- W1980594873 cites W1999464347 @default.
- W1980594873 cites W2000366122 @default.
- W1980594873 cites W2001673874 @default.
- W1980594873 cites W2001756598 @default.
- W1980594873 cites W200202785 @default.
- W1980594873 cites W2002396315 @default.
- W1980594873 cites W2003012286 @default.
- W1980594873 cites W2004290717 @default.
- W1980594873 cites W2009383936 @default.
- W1980594873 cites W2010538029 @default.
- W1980594873 cites W2015199466 @default.
- W1980594873 cites W2016752653 @default.
- W1980594873 cites W2018795884 @default.
- W1980594873 cites W2020455821 @default.
- W1980594873 cites W2030932286 @default.
- W1980594873 cites W2032947861 @default.
- W1980594873 cites W2036127596 @default.
- W1980594873 cites W2037133167 @default.
- W1980594873 cites W2037840717 @default.
- W1980594873 cites W2038052574 @default.
- W1980594873 cites W2038319340 @default.
- W1980594873 cites W2042712910 @default.
- W1980594873 cites W2044410500 @default.
- W1980594873 cites W2048049691 @default.
- W1980594873 cites W2048504768 @default.
- W1980594873 cites W2048814278 @default.
- W1980594873 cites W2050656150 @default.
- W1980594873 cites W2050754173 @default.
- W1980594873 cites W2051995022 @default.
- W1980594873 cites W2054602416 @default.
- W1980594873 cites W2055530646 @default.
- W1980594873 cites W2055546194 @default.
- W1980594873 cites W2056300299 @default.
- W1980594873 cites W2060574521 @default.
- W1980594873 cites W2063572669 @default.
- W1980594873 cites W2066149280 @default.
- W1980594873 cites W2068635250 @default.
- W1980594873 cites W2070214907 @default.
- W1980594873 cites W2070477343 @default.
- W1980594873 cites W2071251390 @default.
- W1980594873 cites W2071425823 @default.
- W1980594873 cites W2072546632 @default.
- W1980594873 cites W2076654201 @default.
- W1980594873 cites W2077094586 @default.
- W1980594873 cites W2083706383 @default.
- W1980594873 cites W2087638630 @default.
- W1980594873 cites W2087746647 @default.
- W1980594873 cites W2089531740 @default.
- W1980594873 cites W2089927014 @default.
- W1980594873 cites W2090618368 @default.
- W1980594873 cites W2091887204 @default.
- W1980594873 cites W2091928819 @default.
- W1980594873 cites W2094303364 @default.
- W1980594873 cites W2094955456 @default.
- W1980594873 cites W2101002332 @default.
- W1980594873 cites W2104943097 @default.
- W1980594873 cites W2106183724 @default.
- W1980594873 cites W2124847934 @default.
- W1980594873 cites W2141753215 @default.