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- W1980598049 abstract "En la actualidad se conoce que todos los fármacos biológicos, incluidos los de estructura totalmente humana, son capaces de inducir una respuesta inmune por parte del huésped, conocida como inmunogenicidad. La presencia de anticuerpos antifármaco puede condicionar los niveles y la función del fármaco y, por lo tanto, el efecto terapéutico e incluso el perfil de seguridad en función de su mecanismo de acción —neutralizante o no neutralizante— y/o de un aclaramiento acelerado. La inmunogenicidad es un factor dinámico a tener en cuenta en la terapia biológica de la psoriasis, en particular en el tratamiento a largo plazo, y en la evaluación de la pérdida secundaria de respuesta. El conocimiento y manejo de la inmunogenicidad de los distintos tratamientos biológicos representa un instrumento útil no solo en la optimización de las estrategias terapéuticas para cada fármaco, sino también en el diseño de modelos predictivos de respuesta, e incluso en la personalización de la terapia. It is now known that all biologic drugs, even those that are fully human, are immunogenic, that is, they have the ability to induce an immune response in the treated patient. Since the presence of antidrug antibodies may influence the levels and function of the drug in the body, this immune response can alter the efficacy of the biologic treatment and even its safety profile, depending on the mechanism of action (neutralizing or nonneutralizing) and/or an accelerated clearance of the drug. Immunogenicity is a dynamic factor that should be taken into account when prescribing biologic therapy in psoriasis, especially in the case of long-term treatment and when assessing secondary loss of response. An understanding of the immunogenicity of biologic therapies and how this can be managed is useful not only for optimizing the treatment strategy used with each drug, but also for designing predictive models of response and even for tailoring therapy on a case-by-case basis." @default.
- W1980598049 created "2016-06-24" @default.
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- W1980598049 date "2013-07-01" @default.
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- W1980598049 title "Inmunogenicidad en terapia biológica. Implicaciones en Dermatología" @default.
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- W1980598049 doi "https://doi.org/10.1016/j.ad.2013.02.005" @default.
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