FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980608200> ?p ?o ?g. }

• W1980608200 endingPage "e79160" @default.
• W1980608200 startingPage "e79160" @default.
• W1980608200 abstract "In recent years, it has become accepted that α-synuclein (αSyn) has a key role in the microglia-mediated neuroinflammation, which accompanies the development of Parkinson’s disease and other related disorders, such as Dementia with Lewy Bodies and Alzheimer’s disease. Nevertheless, the cellular and molecular mechanisms underlying its pathological actions, especially in the sporadic forms of the diseases, are not completely understood. Intriguingly, several epidemiological and animal model studies have revealed a link between certain microbial infections and the onset or progression of sporadic forms of these neurodegenerative disorders. In this work, we have characterized the effect of toll-like receptor (TLR) stimulation on primary murine microglial cultures and analysed the impact of priming cells with extracellular wild-type (Wt) αSyn on the subsequent TLR stimulation of cells with a set of TLR ligands. By assaying key interleukins and chemokines we report that specific stimuli, in particular Pam3Csk4 (Pam3) and single-stranded RNA40 (ssRNA), can differentially affect the TLR2/1- and TLR7-mediated responses of microglia when pre-conditioned with αSyn by augmenting IL-6, MCP-1/CCL2 or IP-10/CXCL10 secretion levels. Furthermore, we report a skewing of αSyn-primed microglia stimulated with ssRNA (TLR7) or Pam3 (TLR2/1) towards intermediate but at the same time differential, M1/M2 phenotypes. Finally, we show that the levels and intracellular location of activated caspase-3 protein change significantly in αSyn-primed microglia after stimulation with these particular TLR agonists. Overall, we report a remarkable impact of non-aggregated αSyn pre-sensitization of microglia on TLR-mediated immunity, a phenomenon that could contribute to triggering the onset of sporadic α-synuclein-related neuropathologies." @default.
• W1980608200 created "2016-06-24" @default.
• W1980608200 creator A5018267294 @default.
• W1980608200 creator A5038180818 @default.
• W1980608200 creator A5045530122 @default.
• W1980608200 creator A5046390320 @default.
• W1980608200 creator A5047947157 @default.
• W1980608200 creator A5063924798 @default.
• W1980608200 creator A5067897234 @default.
• W1980608200 creator A5069358923 @default.
• W1980608200 creator A5072346483 @default.
• W1980608200 creator A5083458459 @default.
• W1980608200 creator A5091295224 @default.
• W1980608200 creator A5091898546 @default.
• W1980608200 date "2013-11-13" @default.
• W1980608200 modified "2023-10-07" @default.
• W1980608200 title "Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation" @default.
• W1980608200 cites W139404515 @default.
• W1980608200 cites W1554600569 @default.
• W1980608200 cites W1588992473 @default.
• W1980608200 cites W1664095504 @default.
• W1980608200 cites W1729621315 @default.
• W1980608200 cites W1822935226 @default.
• W1980608200 cites W1965095016 @default.
• W1980608200 cites W1965575645 @default.
• W1980608200 cites W1968615956 @default.
• W1980608200 cites W1969185518 @default.
• W1980608200 cites W1970606114 @default.
• W1980608200 cites W1973190490 @default.
• W1980608200 cites W1976856337 @default.
• W1980608200 cites W1982207977 @default.
• W1980608200 cites W1986216002 @default.
• W1980608200 cites W2001464444 @default.
• W1980608200 cites W2003260773 @default.
• W1980608200 cites W2004349171 @default.
• W1980608200 cites W2004653921 @default.
• W1980608200 cites W2011719513 @default.
• W1980608200 cites W2013100814 @default.
• W1980608200 cites W2015020748 @default.
• W1980608200 cites W2020495469 @default.
• W1980608200 cites W2026676471 @default.
• W1980608200 cites W2030919251 @default.
• W1980608200 cites W2039008625 @default.
• W1980608200 cites W2039010656 @default.
• W1980608200 cites W2040203980 @default.
• W1980608200 cites W2044728754 @default.
• W1980608200 cites W2045044466 @default.
• W1980608200 cites W2049737588 @default.
• W1980608200 cites W2050091174 @default.
• W1980608200 cites W2050786534 @default.
• W1980608200 cites W2052151366 @default.
• W1980608200 cites W2054868321 @default.
• W1980608200 cites W2056188402 @default.
• W1980608200 cites W2064344027 @default.
• W1980608200 cites W2068495410 @default.
• W1980608200 cites W2073860579 @default.
• W1980608200 cites W2078865976 @default.
• W1980608200 cites W2083799472 @default.
• W1980608200 cites W2083946660 @default.
• W1980608200 cites W2084950627 @default.
• W1980608200 cites W2088258820 @default.
• W1980608200 cites W2089874656 @default.
• W1980608200 cites W2089900719 @default.
• W1980608200 cites W2090840175 @default.
• W1980608200 cites W2091026347 @default.
• W1980608200 cites W2096298540 @default.
• W1980608200 cites W2097795998 @default.
• W1980608200 cites W2103336276 @default.
• W1980608200 cites W2107371790 @default.
• W1980608200 cites W2108060249 @default.
• W1980608200 cites W2110217483 @default.
• W1980608200 cites W2112111711 @default.
• W1980608200 cites W2115993557 @default.
• W1980608200 cites W2116916791 @default.
• W1980608200 cites W2120753166 @default.
• W1980608200 cites W2120950413 @default.
• W1980608200 cites W2122564376 @default.
• W1980608200 cites W2128631317 @default.
• W1980608200 cites W2131222480 @default.
• W1980608200 cites W2131763400 @default.
• W1980608200 cites W2137488766 @default.
• W1980608200 cites W2139463652 @default.
• W1980608200 cites W2141677575 @default.
• W1980608200 cites W2143516276 @default.
• W1980608200 cites W2152168515 @default.
• W1980608200 cites W2156979281 @default.
• W1980608200 cites W2158143414 @default.
• W1980608200 cites W2165186407 @default.
• W1980608200 cites W2167628519 @default.
• W1980608200 cites W4210966129 @default.
• W1980608200 doi "https://doi.org/10.1371/journal.pone.0079160" @default.
• W1980608200 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3827304" @default.
• W1980608200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24236103" @default.
• W1980608200 hasPublicationYear "2013" @default.
• W1980608200 type Work @default.
• W1980608200 sameAs 1980608200 @default.
• W1980608200 citedByCount "79" @default.
• W1980608200 countsByYear W19806082002014 @default.

• next