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• W1980609283 endingPage "433" @default.
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• W1980609283 abstract "Several studies have indicated that the cell-surface expressed nucleolin is implicated in tumorigenesis and angiogenesis, and represents an important target for cancer therapy. Here we show that treatment of rhabdoid tumor derived G401 cells with a nucleolin antagonist, the HB-19 pseudopeptide, could restore contact inhibition, impair anchorage-independent growth, and suppress tumor development in nude mice. G401 cells grow without contact inhibition, which is an in vitro characteristic property of malignant tumor cells. At concentrations of HB-19 that does not affect cell viability and multiplication index, there is restoration of contact inhibition thus suggesting that HB-19 treatment causes reversion of the malignant phenotype. Accordingly, HB-19 pretreated G401 cells lose the capacity to form colonies in soft agar. When assayed for tumorigenicity in nude mice, only 50% of mice injected with HB-19 pretreated G401 cells developed tumors with the mean tumor weight of 0.32 g, compared to 100% of mice injected with control G401 cells with the mean tumor weight of 2.36 g. Interestingly, the restoration of contact inhibition in HB-19 treated G401 cells is concomitant with marked reduction of transcripts coding the Wilms' tumor 1 gene, matrix metalloproteinase-2, epithelial isoform of CD44, and vascular endothelial growth factor, whereas no apparent modification is detected for transcripts coding the proto-oncogene c-Myc, anti-apoptotic Bcl-2, pro-apoptotic Bax, tissue inhibitor of metalloproteinase TIMP-1, angiogenesis inhibitor TSP-1, and growth factor Midkine. These findings indicate that the molecular mechanism of action of HB-19 on such highly malignant rhabdoid tumor cells is associated with a selective inhibitory effect on the expression of genes implicated in tumorigenesis and angiogenesis." @default.
• W1980609283 created "2016-06-24" @default.
• W1980609283 creator A5000206901 @default.
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• W1980609283 date "2011-03-01" @default.
• W1980609283 modified "2023-10-18" @default.
• W1980609283 title "Suppression of tumorigenicity of rhabdoid tumor derived G401 cells by the multivalent HB-19 pseudopeptide that targets surface nucleolin" @default.
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• W1980609283 cites W1925850732 @default.
• W1980609283 cites W1933458349 @default.
• W1980609283 cites W1967722867 @default.
• W1980609283 cites W1967987158 @default.
• W1980609283 cites W1968380007 @default.
• W1980609283 cites W1972018462 @default.
• W1980609283 cites W1972881749 @default.
• W1980609283 cites W1974811837 @default.
• W1980609283 cites W1975071436 @default.
• W1980609283 cites W1976615153 @default.
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• W1980609283 cites W2069296806 @default.
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• W1980609283 doi "https://doi.org/10.1016/j.biochi.2010.10.015" @default.
• W1980609283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21040752" @default.
• W1980609283 hasPublicationYear "2011" @default.
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