FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980670415> ?p ?o ?g. }

• W1980670415 endingPage "891" @default.
• W1980670415 startingPage "882" @default.
• W1980670415 abstract "Previous studies have shown that LR-90, a new inhibitor of AGE formation, prevented the development of experimental type 1 diabetic nephropathy. In this study, we examined the effects of LR-90 in the Zucker diabetic fatty (ZDF) rat, a model of type 2 diabetes and metabolic syndrome, and investigated the mechanisms by which it may protect against renal injury. Male ZDF rats were treated without or with LR-90 from age 13 to 40 weeks. Metabolic and kidney functions and renal histology were evaluated. AGE accumulation and the production of the receptor for AGE (AGER) were measured. Profibrotic growth factors, extracellular matrix proteins and intracellular signalling pathways associated with glomerular and tubular damage were also analysed. LR-90 dramatically reduced plasma lipids in ZDF rats, with only modest effects on hyperglycaemia. Renal AGE, AGER and lipid peroxidation were all attenuated by LR-90. LR-90 significantly retarded the increase in albuminuria and proteinuria. This was associated with reduction in glomerulosclerosis and tubulointerstitial fibrosis, concomitant with marked inhibition of renal overproduction of TGF-β1, connective tissue growth factor, fibronectin and collagen IV. Additionally, LR-90 downregulated the activation of key mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB) in the renal cortex. These results support our earlier studies on the renoprotective effects of LR-90 on type 1 diabetic nephropathy and provide further evidence that LR-90, an AGE inhibitor with pleiotrophic effects, may also be beneficial for the prevention of type 2 diabetic nephropathy, where multiple risk factors, such as hyperglycaemia, dyslipidaemia, obesity, insulin resistance and hypertension, contribute to renal injury." @default.
• W1980670415 created "2016-06-24" @default.
• W1980670415 creator A5027521220 @default.
• W1980670415 creator A5043900353 @default.
• W1980670415 creator A5044129120 @default.
• W1980670415 creator A5044566437 @default.
• W1980670415 creator A5077094708 @default.
• W1980670415 creator A5077437317 @default.
• W1980670415 date "2008-03-04" @default.
• W1980670415 modified "2023-10-07" @default.
• W1980670415 title "LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat" @default.
• W1980670415 cites W1969129502 @default.
• W1980670415 cites W1982173050 @default.
• W1980670415 cites W1983442296 @default.
• W1980670415 cites W1989545182 @default.
• W1980670415 cites W1995021814 @default.
• W1980670415 cites W1996502832 @default.
• W1980670415 cites W1999155792 @default.
• W1980670415 cites W2005362943 @default.
• W1980670415 cites W2011396117 @default.
• W1980670415 cites W2016947895 @default.
• W1980670415 cites W2029719937 @default.
• W1980670415 cites W2032150705 @default.
• W1980670415 cites W2040146794 @default.
• W1980670415 cites W2043867801 @default.
• W1980670415 cites W2048261702 @default.
• W1980670415 cites W2052954861 @default.
• W1980670415 cites W2054704564 @default.
• W1980670415 cites W2060554786 @default.
• W1980670415 cites W2064535158 @default.
• W1980670415 cites W2064793773 @default.
• W1980670415 cites W2065892179 @default.
• W1980670415 cites W2066949987 @default.
• W1980670415 cites W2072372446 @default.
• W1980670415 cites W2080784038 @default.
• W1980670415 cites W2085341182 @default.
• W1980670415 cites W2090969480 @default.
• W1980670415 cites W2102115518 @default.
• W1980670415 cites W2111478784 @default.
• W1980670415 cites W2112461161 @default.
• W1980670415 cites W2119514827 @default.
• W1980670415 cites W2121509432 @default.
• W1980670415 cites W2122981222 @default.
• W1980670415 cites W2126160998 @default.
• W1980670415 cites W2128302560 @default.
• W1980670415 cites W2133568993 @default.
• W1980670415 cites W2133613922 @default.
• W1980670415 cites W2133690273 @default.
• W1980670415 cites W2140491925 @default.
• W1980670415 cites W2140645735 @default.
• W1980670415 cites W2142920097 @default.
• W1980670415 cites W2146385654 @default.
• W1980670415 cites W2149449395 @default.
• W1980670415 cites W2149464736 @default.
• W1980670415 cites W2161026220 @default.
• W1980670415 cites W2319030457 @default.
• W1980670415 cites W4238200498 @default.
• W1980670415 doi "https://doi.org/10.1007/s00125-008-0935-x" @default.
• W1980670415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18317729" @default.
• W1980670415 hasPublicationYear "2008" @default.
• W1980670415 type Work @default.
• W1980670415 sameAs 1980670415 @default.
• W1980670415 citedByCount "47" @default.
• W1980670415 countsByYear W19806704152012 @default.
• W1980670415 countsByYear W19806704152013 @default.
• W1980670415 countsByYear W19806704152014 @default.
• W1980670415 countsByYear W19806704152015 @default.
• W1980670415 countsByYear W19806704152016 @default.
• W1980670415 countsByYear W19806704152017 @default.
• W1980670415 countsByYear W19806704152018 @default.
• W1980670415 countsByYear W19806704152019 @default.
• W1980670415 countsByYear W19806704152020 @default.
• W1980670415 countsByYear W19806704152021 @default.
• W1980670415 countsByYear W19806704152022 @default.
• W1980670415 crossrefType "journal-article" @default.
• W1980670415 hasAuthorship W1980670415A5027521220 @default.
• W1980670415 hasAuthorship W1980670415A5043900353 @default.
• W1980670415 hasAuthorship W1980670415A5044129120 @default.
• W1980670415 hasAuthorship W1980670415A5044566437 @default.
• W1980670415 hasAuthorship W1980670415A5077094708 @default.
• W1980670415 hasAuthorship W1980670415A5077437317 @default.
• W1980670415 hasBestOaLocation W19806704151 @default.
• W1980670415 hasConcept C126322002 @default.
• W1980670415 hasConcept C134018914 @default.
• W1980670415 hasConcept C2776174234 @default.
• W1980670415 hasConcept C2777390665 @default.
• W1980670415 hasConcept C2779561371 @default.
• W1980670415 hasConcept C2779922275 @default.
• W1980670415 hasConcept C2780091579 @default.
• W1980670415 hasConcept C2781184683 @default.
• W1980670415 hasConcept C555293320 @default.
• W1980670415 hasConcept C71924100 @default.
• W1980670415 hasConceptScore W1980670415C126322002 @default.
• W1980670415 hasConceptScore W1980670415C134018914 @default.
• W1980670415 hasConceptScore W1980670415C2776174234 @default.
• W1980670415 hasConceptScore W1980670415C2777390665 @default.
• W1980670415 hasConceptScore W1980670415C2779561371 @default.
• W1980670415 hasConceptScore W1980670415C2779922275 @default.

• next