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- W1980678035 abstract "1 The electrophysiological effects of midaglizole, a new oral hypoglycaemic agent which is an α2-adrenoceptor antagonist, were assessed in the reserpinized ventricular myocardium of the guinea-pig. 2 Midaglizole suppressed the maximal rate of rise (V̇max) and the amplitude of action potentials (APA) of the fast and the slow responses in a concentration-dependent manner without influencing the resting potentials. 3 Voltage-dependency of the V̇max block of the action potentials by midaglizole (10 μm) did not appear in solutions containing various concentrations of KCl. 4 It is concluded that midaglizole has inhibitory effects on the fast Na+ and slow Ca2+ currents of the membrane independent of the blockade of myocardial α-adrenoceptors, and that these effects may be significant in some clinical uses of the drug." @default.
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- W1980678035 date "1991-06-01" @default.
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- W1980678035 title "Effects of midaglizole, a new hypoglycaemic drug on the electrophysiological properties of guinea-pig papillary muscle" @default.
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- W1980678035 doi "https://doi.org/10.1111/j.1476-5381.1991.tb09826.x" @default.
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