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• W1980695662 abstract "Intracerebral dialysis was used to study the mechanism underlying behavioral sensitization. Rats were divided into two groups: a control group that received intraperitoneal injections of saline and an experimental group that was given methamphetamine (MAP) (4 mg/kg) once a day for 14 days. Seven days after the last injection, dopamine (DA) and its metabolites were measured in striatal dialysates obtained from awake freely moving rats. A challenge injection of MAP (4 mg/kg) caused a marked increase in the extracellular concentrations of DA, and the extent of the increase was significantly greater in MAP-pretreated rats than in the saline-pretreated controls. A challenge injection of cocaine (20 mg/kg) also caused a significantly greater increase in extracellular DA levels in MAP-pretreated rats than in saline-pretreated rats. These results suggest that an enhancement in striatal DA efflux may play an important role in MAP-induced behavioral sensitization and cross-sensitization to cocaine." @default.
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• W1980695662 date "1989-04-01" @default.
• W1980695662 modified "2023-09-27" @default.
• W1980695662 title "Subchronic methamphetamine treatment enhances methamphetamine- or cocaine-induced dopamine efflux in vivo" @default.
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• W1980695662 doi "https://doi.org/10.1016/0006-3223(89)90270-9" @default.
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