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- W1980696391 abstract "Cytokines can stimulate the immune response by directly activating effector cells and/or by inducing the release of secondary cytostatic or immunomodulatory molecules. Systemic administration of cytokines, however, often causes numerous side effects in the patient and may not provide a constant level at the tumor site, owing to the variable and generally short half-lifes of cytokines. This has led to the development of novel strategies to deliver cytokines specifically to tumor sites in vivo. These include: the use of monoclonal antibodies directed against tumor antigens; cellular vehicles designed to carry genes to tumor sites; genetically engineered tumor cell vaccines; and targetable viral vectors." @default.
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- W1980696391 date "1996-04-01" @default.
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- W1980696391 title "Site-specific delivery of cytokines in cancer" @default.
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- W1980696391 doi "https://doi.org/10.1016/1357-4310(96)88790-9" @default.
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