FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980712912> ?p ?o ?g. }

• W1980712912 endingPage "234" @default.
• W1980712912 startingPage "226" @default.
• W1980712912 abstract "Our previous work revealed that mice lacking the p50 subunit of transcription factor nuclear factor kappa B (NF-κB) (p50 KO mice) and genetically intact F2 mice have similar locomotion under basal conditions, yet p50 KO mice show greater locomotor activation after caffeine ingestion. In this report, we test whether KO mice display altered caffeine pharmacokinetics or increased caffeine-induced DA turnover relative to F2 mice, and evaluate the impact of intraperitoneal administration of specific adenosine and DA receptor antagonists on locomotor activity. Concentrations of DA and caffeine were measured using high performance liquid chromatography. DA turnover was measured after treatment of mice with an inhibitor of tyrosine hydroxylase. Locomotor activity was measured using telemetry. The data reveal that 1) caffeine concentrations in blood and brain are similar in KO and F2 mice after oral or intraperitoneal administration; 2) KO mice show greater DA turnover under basal conditions, but turnover is similar in both strains after caffeine administration; 3) the specific A2AAR antagonist SCH 58261 induces greater locomotion in KO versus F2 mice; and 4) the activating effect of SCH 58261 in KO mice is prevented by prior treatment with the D2R antagonist raclopride. These findings support the conclusions that 1) A2AAR has a major impact on behavioral activation of p50 KO mice, and 2) D2R mediated neurotransmission is important to this effect." @default.
• W1980712912 created "2016-06-24" @default.
• W1980712912 creator A5012574113 @default.
• W1980712912 creator A5043565774 @default.
• W1980712912 creator A5071163440 @default.
• W1980712912 creator A5071179531 @default.
• W1980712912 creator A5077599665 @default.
• W1980712912 creator A5081100348 @default.
• W1980712912 date "2009-07-01" @default.
• W1980712912 modified "2023-09-24" @default.
• W1980712912 title "Adenosine receptor antagonists and behavioral activation in NF-κB p50 subunit knockout mice" @default.
• W1980712912 cites W109701196 @default.
• W1980712912 cites W1971556351 @default.
• W1980712912 cites W1974384906 @default.
• W1980712912 cites W1988722892 @default.
• W1980712912 cites W1989720567 @default.
• W1980712912 cites W1994970739 @default.
• W1980712912 cites W1996748355 @default.
• W1980712912 cites W1996808726 @default.
• W1980712912 cites W2002933217 @default.
• W1980712912 cites W2028174628 @default.
• W1980712912 cites W2046107045 @default.
• W1980712912 cites W2056083897 @default.
• W1980712912 cites W2066733291 @default.
• W1980712912 cites W2071672292 @default.
• W1980712912 cites W2088155961 @default.
• W1980712912 cites W2095061120 @default.
• W1980712912 cites W2101108802 @default.
• W1980712912 cites W2133531253 @default.
• W1980712912 cites W2163203533 @default.
• W1980712912 cites W2219777068 @default.
• W1980712912 doi "https://doi.org/10.1016/j.lfs.2009.05.016" @default.
• W1980712912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2729109" @default.
• W1980712912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19508875" @default.
• W1980712912 hasPublicationYear "2009" @default.
• W1980712912 type Work @default.
• W1980712912 sameAs 1980712912 @default.
• W1980712912 citedByCount "5" @default.
• W1980712912 countsByYear W19807129122014 @default.
• W1980712912 countsByYear W19807129122016 @default.
• W1980712912 countsByYear W19807129122018 @default.
• W1980712912 crossrefType "journal-article" @default.
• W1980712912 hasAuthorship W1980712912A5012574113 @default.
• W1980712912 hasAuthorship W1980712912A5043565774 @default.
• W1980712912 hasAuthorship W1980712912A5071163440 @default.
• W1980712912 hasAuthorship W1980712912A5071179531 @default.
• W1980712912 hasAuthorship W1980712912A5077599665 @default.
• W1980712912 hasAuthorship W1980712912A5081100348 @default.
• W1980712912 hasBestOaLocation W19807129122 @default.
• W1980712912 hasConcept C126322002 @default.
• W1980712912 hasConcept C134018914 @default.
• W1980712912 hasConcept C170493617 @default.
• W1980712912 hasConcept C182704531 @default.
• W1980712912 hasConcept C185592680 @default.
• W1980712912 hasConcept C2776885963 @default.
• W1980712912 hasConcept C2776991684 @default.
• W1980712912 hasConcept C2778491162 @default.
• W1980712912 hasConcept C2778500429 @default.
• W1980712912 hasConcept C2778938600 @default.
• W1980712912 hasConcept C67907053 @default.
• W1980712912 hasConcept C71924100 @default.
• W1980712912 hasConcept C86803240 @default.
• W1980712912 hasConcept C98274493 @default.
• W1980712912 hasConceptScore W1980712912C126322002 @default.
• W1980712912 hasConceptScore W1980712912C134018914 @default.
• W1980712912 hasConceptScore W1980712912C170493617 @default.
• W1980712912 hasConceptScore W1980712912C182704531 @default.
• W1980712912 hasConceptScore W1980712912C185592680 @default.
• W1980712912 hasConceptScore W1980712912C2776885963 @default.
• W1980712912 hasConceptScore W1980712912C2776991684 @default.
• W1980712912 hasConceptScore W1980712912C2778491162 @default.
• W1980712912 hasConceptScore W1980712912C2778500429 @default.
• W1980712912 hasConceptScore W1980712912C2778938600 @default.
• W1980712912 hasConceptScore W1980712912C67907053 @default.
• W1980712912 hasConceptScore W1980712912C71924100 @default.
• W1980712912 hasConceptScore W1980712912C86803240 @default.
• W1980712912 hasConceptScore W1980712912C98274493 @default.
• W1980712912 hasIssue "5-6" @default.
• W1980712912 hasLocation W19807129121 @default.
• W1980712912 hasLocation W19807129122 @default.
• W1980712912 hasLocation W19807129123 @default.
• W1980712912 hasLocation W19807129124 @default.
• W1980712912 hasOpenAccess W1980712912 @default.
• W1980712912 hasPrimaryLocation W19807129121 @default.
• W1980712912 hasRelatedWork W1975391500 @default.
• W1980712912 hasRelatedWork W2006366986 @default.
• W1980712912 hasRelatedWork W2036169877 @default.
• W1980712912 hasRelatedWork W2040473331 @default.
• W1980712912 hasRelatedWork W2056166855 @default.
• W1980712912 hasRelatedWork W2084705555 @default.
• W1980712912 hasRelatedWork W2139132107 @default.
• W1980712912 hasRelatedWork W2160911543 @default.
• W1980712912 hasRelatedWork W2418064081 @default.
• W1980712912 hasRelatedWork W974957739 @default.
• W1980712912 hasVolume "85" @default.
• W1980712912 isParatext "false" @default.
• W1980712912 isRetracted "false" @default.
• W1980712912 magId "1980712912" @default.

• next