Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980721507> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1980721507 endingPage "5023" @default.
- W1980721507 startingPage "5017" @default.
- W1980721507 abstract "erh (enhancer of rudimentary homolog) is a ubiquitously expressed transcriptional coregulator that is highly conserved among eukaryotes, from humans to plants to protozoa. Functions attributed to erh include enhancement of pyrimidine biosynthesis, a role in cell cycle regulation, and repression of the tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1) through binding the coactivator DCoH (dimerization cofactor of HNF1). No homologous sequences, other than erh orthologs, have been identified, and little is known about the interactions of erh. To further elucidate its function, we determined the crystal structure of erh to 2.0 A resolution. The erh structure is a novel alpha + beta fold consisting of a four-stranded antiparallel beta sheet with three amphipathic alpha helices situated on one face of the beta sheet. Structure-based searches of the Protein Data Bank, like sequence-based searches, failed to identify paralogs. We present structural and biochemical evidence that erh functions as a dimer. The dimer interface consists of a beta sandwich composed of the beta sheet from each monomer. Many of the surface residues of erh are conserved, including patches of hydrophobic and charged residues, suggesting protein-protein interaction interfaces. Two putative CKII phosphorylation sites are highly ordered in the structure and are predicted to disrupt dimerization and protein-protein interactions." @default.
- W1980721507 created "2016-06-24" @default.
- W1980721507 creator A5001919234 @default.
- W1980721507 creator A5030919384 @default.
- W1980721507 creator A5052743446 @default.
- W1980721507 creator A5071038346 @default.
- W1980721507 creator A5074238831 @default.
- W1980721507 date "2005-03-03" @default.
- W1980721507 modified "2023-10-03" @default.
- W1980721507 title "Structure of the Conserved Transcriptional Repressor Enhancer of Rudimentary Homolog<sup>,</sup>" @default.
- W1980721507 cites W1037183200 @default.
- W1980721507 cites W1876608478 @default.
- W1980721507 cites W1999590520 @default.
- W1980721507 cites W2007451197 @default.
- W1980721507 cites W2038163496 @default.
- W1980721507 cites W2060807817 @default.
- W1980721507 cites W2084466582 @default.
- W1980721507 cites W2122109248 @default.
- W1980721507 cites W2135839939 @default.
- W1980721507 doi "https://doi.org/10.1021/bi047785w" @default.
- W1980721507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15794639" @default.
- W1980721507 hasPublicationYear "2005" @default.
- W1980721507 type Work @default.
- W1980721507 sameAs 1980721507 @default.
- W1980721507 citedByCount "35" @default.
- W1980721507 countsByYear W19807215072012 @default.
- W1980721507 countsByYear W19807215072013 @default.
- W1980721507 countsByYear W19807215072015 @default.
- W1980721507 countsByYear W19807215072016 @default.
- W1980721507 countsByYear W19807215072017 @default.
- W1980721507 countsByYear W19807215072019 @default.
- W1980721507 countsByYear W19807215072020 @default.
- W1980721507 countsByYear W19807215072021 @default.
- W1980721507 countsByYear W19807215072022 @default.
- W1980721507 countsByYear W19807215072023 @default.
- W1980721507 crossrefType "journal-article" @default.
- W1980721507 hasAuthorship W1980721507A5001919234 @default.
- W1980721507 hasAuthorship W1980721507A5030919384 @default.
- W1980721507 hasAuthorship W1980721507A5052743446 @default.
- W1980721507 hasAuthorship W1980721507A5071038346 @default.
- W1980721507 hasAuthorship W1980721507A5074238831 @default.
- W1980721507 hasConcept C104317684 @default.
- W1980721507 hasConcept C107824862 @default.
- W1980721507 hasConcept C111936080 @default.
- W1980721507 hasConcept C115260700 @default.
- W1980721507 hasConcept C121332964 @default.
- W1980721507 hasConcept C142089489 @default.
- W1980721507 hasConcept C158448853 @default.
- W1980721507 hasConcept C167625842 @default.
- W1980721507 hasConcept C185592680 @default.
- W1980721507 hasConcept C199216141 @default.
- W1980721507 hasConcept C47701112 @default.
- W1980721507 hasConcept C55493867 @default.
- W1980721507 hasConcept C62520636 @default.
- W1980721507 hasConcept C77445288 @default.
- W1980721507 hasConcept C86339819 @default.
- W1980721507 hasConcept C86803240 @default.
- W1980721507 hasConcept C95444343 @default.
- W1980721507 hasConceptScore W1980721507C104317684 @default.
- W1980721507 hasConceptScore W1980721507C107824862 @default.
- W1980721507 hasConceptScore W1980721507C111936080 @default.
- W1980721507 hasConceptScore W1980721507C115260700 @default.
- W1980721507 hasConceptScore W1980721507C121332964 @default.
- W1980721507 hasConceptScore W1980721507C142089489 @default.
- W1980721507 hasConceptScore W1980721507C158448853 @default.
- W1980721507 hasConceptScore W1980721507C167625842 @default.
- W1980721507 hasConceptScore W1980721507C185592680 @default.
- W1980721507 hasConceptScore W1980721507C199216141 @default.
- W1980721507 hasConceptScore W1980721507C47701112 @default.
- W1980721507 hasConceptScore W1980721507C55493867 @default.
- W1980721507 hasConceptScore W1980721507C62520636 @default.
- W1980721507 hasConceptScore W1980721507C77445288 @default.
- W1980721507 hasConceptScore W1980721507C86339819 @default.
- W1980721507 hasConceptScore W1980721507C86803240 @default.
- W1980721507 hasConceptScore W1980721507C95444343 @default.
- W1980721507 hasIssue "13" @default.
- W1980721507 hasLocation W19807215071 @default.
- W1980721507 hasLocation W19807215072 @default.
- W1980721507 hasOpenAccess W1980721507 @default.
- W1980721507 hasPrimaryLocation W19807215071 @default.
- W1980721507 hasRelatedWork W1980721507 @default.
- W1980721507 hasRelatedWork W2062876308 @default.
- W1980721507 hasRelatedWork W2063456921 @default.
- W1980721507 hasRelatedWork W2067931052 @default.
- W1980721507 hasRelatedWork W2101962116 @default.
- W1980721507 hasRelatedWork W2410749618 @default.
- W1980721507 hasRelatedWork W2570668323 @default.
- W1980721507 hasRelatedWork W3041586085 @default.
- W1980721507 hasRelatedWork W3201423902 @default.
- W1980721507 hasRelatedWork W4285169569 @default.
- W1980721507 hasVolume "44" @default.
- W1980721507 isParatext "false" @default.
- W1980721507 isRetracted "false" @default.
- W1980721507 magId "1980721507" @default.
- W1980721507 workType "article" @default.