FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980737383> ?p ?o ?g. }

• W1980737383 endingPage "179" @default.
• W1980737383 startingPage "167" @default.
• W1980737383 abstract "Years ago, ischemic stroke was regarded as a model disease for the development of neuroprotective therapies by the pharmacological industry. Results were disappointing. There are still no treatments available allowing the rescue of brain tissue once a stroke has occurred. Study failure is not only a problem in the stroke field. In other neurodegenerative conditions and in non-degenerative brain disorders, progress in drug development was also rather scarce until recently. An important factor in drug failure is the blood-brain barrier, which expresses active transporters that eliminate drugs from the brain. These transporters exhibit strong variations between different animals, which make it difficult to predict brain concentrations of drugs over species barriers. This paper claims that more detailed knowledge about: (1) the biology of blood-brain barrier transporters; (2) their regulation in brain disease, (3) the affinity of transporters to candidate drugs; and (4) the accumulation of drugs in brain tissue is needed for the overall success of clinical trials to be improved. An alternative strategy could be the use of disease-modifying treatments that do not have to enter the brain to exert their function. As such, restorative and anti-inflammatory strategies acting at the blood-brain interface might gain therapeutic potential in the future." @default.
• W1980737383 created "2016-06-24" @default.
• W1980737383 creator A5028410367 @default.
• W1980737383 date "2008-11-01" @default.
• W1980737383 modified "2023-09-24" @default.
• W1980737383 title "Review: Future perspectives for brain pharmacotherapies: implications of drug transport processes at the blood—brain barrier" @default.
• W1980737383 cites W1779791888 @default.
• W1980737383 cites W1848977294 @default.
• W1980737383 cites W1941252177 @default.
• W1980737383 cites W1965387410 @default.
• W1980737383 cites W1966420953 @default.
• W1980737383 cites W1967577319 @default.
• W1980737383 cites W1971901938 @default.
• W1980737383 cites W1974898218 @default.
• W1980737383 cites W1974962627 @default.
• W1980737383 cites W1975085253 @default.
• W1980737383 cites W1978255324 @default.
• W1980737383 cites W1978404200 @default.
• W1980737383 cites W1979761775 @default.
• W1980737383 cites W1981047775 @default.
• W1980737383 cites W1983835769 @default.
• W1980737383 cites W1986228861 @default.
• W1980737383 cites W1987126752 @default.
• W1980737383 cites W1991861283 @default.
• W1980737383 cites W1994348363 @default.
• W1980737383 cites W1995883711 @default.
• W1980737383 cites W2000962264 @default.
• W1980737383 cites W2002557206 @default.
• W1980737383 cites W2006434892 @default.
• W1980737383 cites W2006904109 @default.
• W1980737383 cites W2007847945 @default.
• W1980737383 cites W2008303238 @default.
• W1980737383 cites W2015541518 @default.
• W1980737383 cites W2019582599 @default.
• W1980737383 cites W2020475471 @default.
• W1980737383 cites W2025082561 @default.
• W1980737383 cites W2025388522 @default.
• W1980737383 cites W2026257843 @default.
• W1980737383 cites W2031483215 @default.
• W1980737383 cites W2032897292 @default.
• W1980737383 cites W2041436541 @default.
• W1980737383 cites W2046493948 @default.
• W1980737383 cites W2048049968 @default.
• W1980737383 cites W2050942708 @default.
• W1980737383 cites W2053442326 @default.
• W1980737383 cites W2054458932 @default.
• W1980737383 cites W205495280 @default.
• W1980737383 cites W2060382789 @default.
• W1980737383 cites W2063288921 @default.
• W1980737383 cites W2064546177 @default.
• W1980737383 cites W2068801152 @default.
• W1980737383 cites W2068969996 @default.
• W1980737383 cites W2071924270 @default.
• W1980737383 cites W2072639955 @default.
• W1980737383 cites W2077459688 @default.
• W1980737383 cites W2079394559 @default.
• W1980737383 cites W2084498863 @default.
• W1980737383 cites W2088542086 @default.
• W1980737383 cites W2089999232 @default.
• W1980737383 cites W2092108048 @default.
• W1980737383 cites W2092962006 @default.
• W1980737383 cites W2094691824 @default.
• W1980737383 cites W2098938825 @default.
• W1980737383 cites W2103274980 @default.
• W1980737383 cites W2103758700 @default.
• W1980737383 cites W2105118307 @default.
• W1980737383 cites W2108641213 @default.
• W1980737383 cites W2110371901 @default.
• W1980737383 cites W2112505121 @default.
• W1980737383 cites W2112646710 @default.
• W1980737383 cites W2122637273 @default.
• W1980737383 cites W2125809720 @default.
• W1980737383 cites W2126878602 @default.
• W1980737383 cites W2136280619 @default.
• W1980737383 cites W2138898583 @default.
• W1980737383 cites W2144239482 @default.
• W1980737383 cites W2146535066 @default.
• W1980737383 cites W2149016411 @default.
• W1980737383 cites W2152841022 @default.
• W1980737383 cites W2153508530 @default.
• W1980737383 cites W2157368934 @default.
• W1980737383 cites W2157635452 @default.
• W1980737383 cites W2158882381 @default.
• W1980737383 cites W2160291688 @default.
• W1980737383 cites W2160582541 @default.
• W1980737383 cites W2162978741 @default.
• W1980737383 cites W2163636362 @default.
• W1980737383 cites W2166050160 @default.
• W1980737383 cites W2188223674 @default.
• W1980737383 cites W2292308933 @default.
• W1980737383 cites W2340133307 @default.
• W1980737383 cites W49683220 @default.
• W1980737383 cites W84182309 @default.
• W1980737383 doi "https://doi.org/10.1177/1756285608097775" @default.
• W1980737383 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3002556" @default.
• W1980737383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21180575" @default.
• W1980737383 hasPublicationYear "2008" @default.
• W1980737383 type Work @default.

• next