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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980739283> ?p ?o ?g. }

• W1980739283 endingPage "4954" @default.
• W1980739283 startingPage "4950" @default.
• W1980739283 abstract "In culture, cAMP is known to be mitogenic for mammary cells and several other epithelia, but evidence for a similar role in vivo has been only correlative. We have used plastic implants to cause slow release of cholera toxin and other cAMP-active agents to local areas of mammary glands in ovariectomized mice. Elevated levels of intracellular cAMP around the implants promoted vigorous growth and normal ductal morphogenesis, while distant sites were unaffected. Local effects of cAMP included restoration of normal ductal caliber, formation of new end buds, and reinitiation of DNA synthesis in both epithelium and surrounding stroma. Thus, cAMP is both a mitogenic and a morphogenetic factor in this tissue." @default.
• W1980739283 created "2016-06-24" @default.
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• W1980739283 date "1984-08-01" @default.
• W1980739283 modified "2023-09-27" @default.
• W1980739283 title "In vivo, cAMP stimulates growth and morphogenesis of mouse mammary ducts." @default.
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• W1980739283 doi "https://doi.org/10.1073/pnas.81.15.4950" @default.
• W1980739283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/391610" @default.
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