FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980753615> ?p ?o ?g. }

• W1980753615 endingPage "244" @default.
• W1980753615 startingPage "237" @default.
• W1980753615 abstract "Although the bone anabolic properties of intermittent parathyroid hormone (PTH) have long been employed in the treatment of osteoporosis, the molecular mechanisms behind this action remain largely unknown. Previous studies showed that PTH increases the expression and the activity of epidermal growth factor receptor (EGFR) in osteoblasts, and activation of ERK1/2 by PTH in osteoblasts was demonstrated to induce the proteolytical release of EGFR ligands and EGFR transactivation. However, conclusive evidence for an important role of the EGFR system in mediating the anabolic actions of intermittent PTH on bone in vivo is lacking. Here, we evaluated the effects of intermittent PTH on bone in Waved-5 (Wa5) mice which carry an antimorphic Egfr allele whose product acts as a dominant negative receptor. Heterozygous Wa5 females and control littermates received a subcutaneous injection of PTH (80 μg/kg) or buffer on 5 days per week for 4 weeks. Wa5 mice had slightly lower total bone mineral density (BMD), but normal cancellous bone volume and turnover in the distal femoral metaphysis. The presence of the antimorphic Egfr allele neither influenced the PTH-induced increase in serum osteocalcin nor the increases in distal femoral BMD, cortical thickness, cancellous bone volume, and cancellous bone formation rate. Similarly, the PTH-induced rise in lumbar vertebral BMD was unchanged in Wa5 relative to wild-type mice. Wa5-derived osteoblasts showed considerably lower basal extracellular signal-regulated kinase 1/2 (ERK1/2) activation as compared to control osteoblasts. Whereas activation of ERK1/2 by the EGFR ligand amphiregulin was largely blocked in Wa5 osteoblasts, treatment with PTH induced ERK1/2 activation comparable to that observed in control osteoblasts, relative to baseline levels. Our data indicate that impairment of EGFR signaling does not affect the anabolic action of intermittent PTH on cancellous and cortical bone." @default.
• W1980753615 created "2016-06-24" @default.
• W1980753615 creator A5010329657 @default.
• W1980753615 creator A5015784806 @default.
• W1980753615 creator A5023390854 @default.
• W1980753615 creator A5024292257 @default.
• W1980753615 creator A5029759771 @default.
• W1980753615 creator A5052931841 @default.
• W1980753615 creator A5058815350 @default.
• W1980753615 creator A5059259482 @default.
• W1980753615 creator A5062610054 @default.
• W1980753615 date "2012-01-01" @default.
• W1980753615 modified "2023-10-17" @default.
• W1980753615 title "Normal epidermal growth factor receptor signaling is dispensable for bone anabolic effects of parathyroid hormone" @default.
• W1980753615 cites W1966846879 @default.
• W1980753615 cites W1968093456 @default.
• W1980753615 cites W1987153472 @default.
• W1980753615 cites W1992160099 @default.
• W1980753615 cites W1992913621 @default.
• W1980753615 cites W1995632240 @default.
• W1980753615 cites W1997430719 @default.
• W1980753615 cites W1997688114 @default.
• W1980753615 cites W2000460174 @default.
• W1980753615 cites W2002273560 @default.
• W1980753615 cites W2004217766 @default.
• W1980753615 cites W2011642803 @default.
• W1980753615 cites W2029202516 @default.
• W1980753615 cites W2040980521 @default.
• W1980753615 cites W2046819829 @default.
• W1980753615 cites W2054510931 @default.
• W1980753615 cites W2058646964 @default.
• W1980753615 cites W2065426268 @default.
• W1980753615 cites W2066104914 @default.
• W1980753615 cites W2067376187 @default.
• W1980753615 cites W2067411979 @default.
• W1980753615 cites W2068122204 @default.
• W1980753615 cites W2075375114 @default.
• W1980753615 cites W2076064293 @default.
• W1980753615 cites W2078888308 @default.
• W1980753615 cites W2080035405 @default.
• W1980753615 cites W2082738785 @default.
• W1980753615 cites W2087549132 @default.
• W1980753615 cites W2087692142 @default.
• W1980753615 cites W2089139414 @default.
• W1980753615 cites W2096108304 @default.
• W1980753615 cites W2109380474 @default.
• W1980753615 cites W2110664092 @default.
• W1980753615 cites W2126415744 @default.
• W1980753615 cites W2163778784 @default.
• W1980753615 cites W2171087186 @default.
• W1980753615 doi "https://doi.org/10.1016/j.bone.2011.10.019" @default.
• W1980753615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22056328" @default.
• W1980753615 hasPublicationYear "2012" @default.
• W1980753615 type Work @default.
• W1980753615 sameAs 1980753615 @default.
• W1980753615 citedByCount "12" @default.
• W1980753615 countsByYear W19807536152012 @default.
• W1980753615 countsByYear W19807536152013 @default.
• W1980753615 countsByYear W19807536152015 @default.
• W1980753615 countsByYear W19807536152016 @default.
• W1980753615 countsByYear W19807536152017 @default.
• W1980753615 countsByYear W19807536152021 @default.
• W1980753615 crossrefType "journal-article" @default.
• W1980753615 hasAuthorship W1980753615A5010329657 @default.
• W1980753615 hasAuthorship W1980753615A5015784806 @default.
• W1980753615 hasAuthorship W1980753615A5023390854 @default.
• W1980753615 hasAuthorship W1980753615A5024292257 @default.
• W1980753615 hasAuthorship W1980753615A5029759771 @default.
• W1980753615 hasAuthorship W1980753615A5052931841 @default.
• W1980753615 hasAuthorship W1980753615A5058815350 @default.
• W1980753615 hasAuthorship W1980753615A5059259482 @default.
• W1980753615 hasAuthorship W1980753615A5062610054 @default.
• W1980753615 hasConcept C1008401 @default.
• W1980753615 hasConcept C105702510 @default.
• W1980753615 hasConcept C126322002 @default.
• W1980753615 hasConcept C131075544 @default.
• W1980753615 hasConcept C134018914 @default.
• W1980753615 hasConcept C160160445 @default.
• W1980753615 hasConcept C170033053 @default.
• W1980753615 hasConcept C181199279 @default.
• W1980753615 hasConcept C185592680 @default.
• W1980753615 hasConcept C2776350087 @default.
• W1980753615 hasConcept C2776541429 @default.
• W1980753615 hasConcept C2776886416 @default.
• W1980753615 hasConcept C2778879140 @default.
• W1980753615 hasConcept C2781208988 @default.
• W1980753615 hasConcept C2781451080 @default.
• W1980753615 hasConcept C519063684 @default.
• W1980753615 hasConcept C55493867 @default.
• W1980753615 hasConcept C71924100 @default.
• W1980753615 hasConceptScore W1980753615C1008401 @default.
• W1980753615 hasConceptScore W1980753615C105702510 @default.
• W1980753615 hasConceptScore W1980753615C126322002 @default.
• W1980753615 hasConceptScore W1980753615C131075544 @default.
• W1980753615 hasConceptScore W1980753615C134018914 @default.
• W1980753615 hasConceptScore W1980753615C160160445 @default.
• W1980753615 hasConceptScore W1980753615C170033053 @default.
• W1980753615 hasConceptScore W1980753615C181199279 @default.

• next