FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980753781> ?p ?o ?g. }

• W1980753781 endingPage "275" @default.
• W1980753781 startingPage "267" @default.
• W1980753781 abstract "The effects of guanabenz, guanfacine and Clonidine on α-adrenoceptors were investigated in isolated rat vas deferens and rabbit aortic strip. All 3 drugs at low concentrations (10-9–10-8 M) caused inhibition of twitch responses of the rat vas deferens induced by nerve stimulation. These effects were competitively antagonized by yohimbine. Guanfacine and Clonidine at relatively high concentrations (10-6–10-4 M) produced contractions of the rat vas deferens which were antagonized by prazosin. These contractile responses were not much affected by denervation. Prazosin-sensitive contractions by guanfacine and Clonidine were also observed in the rabbit aortic strip, which were not affected by reserpine pretreatment. In both tissues, the intrinsic activity of guanfacine was almost identical to that of norepinephrine, whereas that of Clonidine was less than one half. Guanabenz and Clonidine showed a competitive antagonistic effect against norepinephrine and phenylephrine in both the rat vas deferens and rabbit aorta, the antagonisms being similar in potency. The results indicate that all 3 drugs are potent agonists on the presynaptic α2-adrenoceptor. In contrast, on the postsynaptic α1-adrenoceptor, guanfacine and guanabenz showed only agonistic and antagonistic actions, respectively, whereas Clonidine exhibited partial agonistic characteristics." @default.
• W1980753781 created "2016-06-24" @default.
• W1980753781 creator A5014311489 @default.
• W1980753781 creator A5052916925 @default.
• W1980753781 creator A5074324034 @default.
• W1980753781 date "1987-01-01" @default.
• W1980753781 modified "2023-10-06" @default.
• W1980753781 title "Comparison of agonistic and antagonistic actions of guanabenz and guanfacin on .ALPHA.1 and .ALPHA.2-adrenoceptors in isolated smooth muscles." @default.
• W1980753781 cites W1970908266 @default.
• W1980753781 cites W1987592050 @default.
• W1980753781 cites W1998845488 @default.
• W1980753781 cites W2015497163 @default.
• W1980753781 cites W2023140990 @default.
• W1980753781 cites W2028012319 @default.
• W1980753781 cites W2030752853 @default.
• W1980753781 cites W2037684010 @default.
• W1980753781 cites W2047941173 @default.
• W1980753781 cites W2055320228 @default.
• W1980753781 cites W2058072946 @default.
• W1980753781 cites W2059472677 @default.
• W1980753781 cites W2063043376 @default.
• W1980753781 cites W2072920312 @default.
• W1980753781 cites W2076380276 @default.
• W1980753781 cites W2094620490 @default.
• W1980753781 cites W2240727753 @default.
• W1980753781 cites W2302863210 @default.
• W1980753781 cites W2398471649 @default.
• W1980753781 cites W2409432023 @default.
• W1980753781 cites W2411058251 @default.
• W1980753781 cites W44420309 @default.
• W1980753781 doi "https://doi.org/10.1254/jjp.43.267" @default.
• W1980753781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2884339" @default.
• W1980753781 hasPublicationYear "1987" @default.
• W1980753781 type Work @default.
• W1980753781 sameAs 1980753781 @default.
• W1980753781 citedByCount "7" @default.
• W1980753781 countsByYear W19807537812015 @default.
• W1980753781 countsByYear W19807537812021 @default.
• W1980753781 crossrefType "journal-article" @default.
• W1980753781 hasAuthorship W1980753781A5014311489 @default.
• W1980753781 hasAuthorship W1980753781A5052916925 @default.
• W1980753781 hasAuthorship W1980753781A5074324034 @default.
• W1980753781 hasBestOaLocation W19807537811 @default.
• W1980753781 hasConcept C126322002 @default.
• W1980753781 hasConcept C134018914 @default.
• W1980753781 hasConcept C159110408 @default.
• W1980753781 hasConcept C170493617 @default.
• W1980753781 hasConcept C185592680 @default.
• W1980753781 hasConcept C2775944032 @default.
• W1980753781 hasConcept C2776504411 @default.
• W1980753781 hasConcept C2776885963 @default.
• W1980753781 hasConcept C2777676773 @default.
• W1980753781 hasConcept C2777842393 @default.
• W1980753781 hasConcept C2777952589 @default.
• W1980753781 hasConcept C2778210472 @default.
• W1980753781 hasConcept C2778399450 @default.
• W1980753781 hasConcept C2778680573 @default.
• W1980753781 hasConcept C2778938600 @default.
• W1980753781 hasConcept C2780648677 @default.
• W1980753781 hasConcept C2780815205 @default.
• W1980753781 hasConcept C49453240 @default.
• W1980753781 hasConcept C64943373 @default.
• W1980753781 hasConcept C71924100 @default.
• W1980753781 hasConcept C84393581 @default.
• W1980753781 hasConcept C98274493 @default.
• W1980753781 hasConceptScore W1980753781C126322002 @default.
• W1980753781 hasConceptScore W1980753781C134018914 @default.
• W1980753781 hasConceptScore W1980753781C159110408 @default.
• W1980753781 hasConceptScore W1980753781C170493617 @default.
• W1980753781 hasConceptScore W1980753781C185592680 @default.
• W1980753781 hasConceptScore W1980753781C2775944032 @default.
• W1980753781 hasConceptScore W1980753781C2776504411 @default.
• W1980753781 hasConceptScore W1980753781C2776885963 @default.
• W1980753781 hasConceptScore W1980753781C2777676773 @default.
• W1980753781 hasConceptScore W1980753781C2777842393 @default.
• W1980753781 hasConceptScore W1980753781C2777952589 @default.
• W1980753781 hasConceptScore W1980753781C2778210472 @default.
• W1980753781 hasConceptScore W1980753781C2778399450 @default.
• W1980753781 hasConceptScore W1980753781C2778680573 @default.
• W1980753781 hasConceptScore W1980753781C2778938600 @default.
• W1980753781 hasConceptScore W1980753781C2780648677 @default.
• W1980753781 hasConceptScore W1980753781C2780815205 @default.
• W1980753781 hasConceptScore W1980753781C49453240 @default.
• W1980753781 hasConceptScore W1980753781C64943373 @default.
• W1980753781 hasConceptScore W1980753781C71924100 @default.
• W1980753781 hasConceptScore W1980753781C84393581 @default.
• W1980753781 hasConceptScore W1980753781C98274493 @default.
• W1980753781 hasIssue "3" @default.
• W1980753781 hasLocation W19807537811 @default.
• W1980753781 hasLocation W19807537812 @default.
• W1980753781 hasOpenAccess W1980753781 @default.
• W1980753781 hasPrimaryLocation W19807537811 @default.
• W1980753781 hasRelatedWork W1980606392 @default.
• W1980753781 hasRelatedWork W1980753781 @default.
• W1980753781 hasRelatedWork W1984840840 @default.
• W1980753781 hasRelatedWork W2001569974 @default.
• W1980753781 hasRelatedWork W2007942013 @default.
• W1980753781 hasRelatedWork W2037108296 @default.

• next