FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980798799> ?p ?o ?g. }

• W1980798799 endingPage "2193" @default.
• W1980798799 startingPage "2179" @default.
• W1980798799 abstract "2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed during the cooking of meats. PhIP is a potential human carcinogen: it undergoes metabolic activation to form electrophilic metabolites that bind to DNA and proteins, including serum albumin (SA). The structures of PhIP-SA adducts formed in vivo are unknown and require elucidation before PhIP protein adducts can be implemented as biomarkers in human studies. We previously examined the reaction of genotoxic N-oxidized metabolites of PhIP with human SA in vitro and identified covalent adducts formed at cysteine34 (Cys34); however, other adduction products were thought to occur. We have now identified adducts of PhIP formed at multiple sites of SA reacted with isotopic mixtures of electrophilic metabolites of PhIP and 2-amino-1-methyl-6-[2H5]-phenylimidazo[4,5-b]pyridine ([2H5]-PhIP). The metabolites used for study were 2-nitro-1-methyl-6-phenylimidazo[4,5-b]pyridine (NO2-PhIP), 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (HONH-PhIP), or N-acetyloxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-acetoxy-PhIP). Following proteolytic digestion, PhIP-adducted peptides were separated by ultra performance liquid chromatography and characterized by ion trap mass spectrometry, employing isotopic data-dependent scanning. Analysis of the tryptic or tryptic/chymotryptic digests of SA modified with NO2-PhIP revealed that adduction occurred at Cys34, Lys195, Lys199, Lys351, Lys541, Tyr138, Tyr150, Tyr401, and Tyr411, whereas the only site of HONH-PhIP adduction was detected at Cys34. N-Acetoxy-PhIP, a penultimate metabolite of PhIP that reacts with DNA to form covalent adducts, did not appear to form stable adducts with SA; instead, PhIP and 2-amino-1-methyl-6-(5-hydroxy)-phenylimidazo[4,5-b]pyridine, an aqueous reaction product of the proposed nitrenium ion of PhIP, were recovered during the proteolysis of N-acetoxy-PhIP-modified SA. Some of these SA adduction products of PhIP may be implemented in molecular epidemiology studies to assess the role of well-done cooked meat, PhIP, and the risk of cancer." @default.
• W1980798799 created "2016-06-24" @default.
• W1980798799 creator A5016822440 @default.
• W1980798799 creator A5043108427 @default.
• W1980798799 creator A5062939937 @default.
• W1980798799 creator A5064721834 @default.
• W1980798799 date "2012-08-14" @default.
• W1980798799 modified "2023-10-01" @default.
• W1980798799 title "Mapping Serum Albumin Adducts of the Food-Borne Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine by Data-Dependent Tandem Mass Spectrometry" @default.
• W1980798799 cites W1489541301 @default.
• W1980798799 cites W1504792186 @default.
• W1980798799 cites W1968418371 @default.
• W1980798799 cites W1972017349 @default.
• W1980798799 cites W1974534288 @default.
• W1980798799 cites W1975011110 @default.
• W1980798799 cites W1976095605 @default.
• W1980798799 cites W1976481158 @default.
• W1980798799 cites W1976720273 @default.
• W1980798799 cites W1976952986 @default.
• W1980798799 cites W1977397173 @default.
• W1980798799 cites W1980597876 @default.
• W1980798799 cites W1982379189 @default.
• W1980798799 cites W1982448585 @default.
• W1980798799 cites W1987914210 @default.
• W1980798799 cites W1991518289 @default.
• W1980798799 cites W1998880088 @default.
• W1980798799 cites W2001431794 @default.
• W1980798799 cites W2003981071 @default.
• W1980798799 cites W2006297498 @default.
• W1980798799 cites W2008368893 @default.
• W1980798799 cites W2012012214 @default.
• W1980798799 cites W2014352349 @default.
• W1980798799 cites W2021071169 @default.
• W1980798799 cites W2022295820 @default.
• W1980798799 cites W2022522809 @default.
• W1980798799 cites W2022825159 @default.
• W1980798799 cites W2027974246 @default.
• W1980798799 cites W2031027489 @default.
• W1980798799 cites W2032794463 @default.
• W1980798799 cites W2034195216 @default.
• W1980798799 cites W2035492888 @default.
• W1980798799 cites W2042014666 @default.
• W1980798799 cites W2043645233 @default.
• W1980798799 cites W2053182546 @default.
• W1980798799 cites W2053573662 @default.
• W1980798799 cites W2053775815 @default.
• W1980798799 cites W2057900790 @default.
• W1980798799 cites W2060365113 @default.
• W1980798799 cites W2062742701 @default.
• W1980798799 cites W2065240048 @default.
• W1980798799 cites W2069316248 @default.
• W1980798799 cites W2070783401 @default.
• W1980798799 cites W2072828753 @default.
• W1980798799 cites W2073654287 @default.
• W1980798799 cites W2083272062 @default.
• W1980798799 cites W2087506129 @default.
• W1980798799 cites W2088547129 @default.
• W1980798799 cites W2088718341 @default.
• W1980798799 cites W2088917280 @default.
• W1980798799 cites W2089841771 @default.
• W1980798799 cites W2091164111 @default.
• W1980798799 cites W2091375086 @default.
• W1980798799 cites W2093177181 @default.
• W1980798799 cites W2100930007 @default.
• W1980798799 cites W2102569711 @default.
• W1980798799 cites W2118138596 @default.
• W1980798799 cites W2119446315 @default.
• W1980798799 cites W2134302453 @default.
• W1980798799 cites W2150611725 @default.
• W1980798799 cites W2152604288 @default.
• W1980798799 cites W2157382699 @default.
• W1980798799 cites W2164041166 @default.
• W1980798799 cites W2166537701 @default.
• W1980798799 cites W2329189728 @default.
• W1980798799 cites W2333363395 @default.
• W1980798799 cites W4211146992 @default.
• W1980798799 cites W597942352 @default.
• W1980798799 doi "https://doi.org/10.1021/tx300253j" @default.
• W1980798799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3544159" @default.
• W1980798799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22827630" @default.
• W1980798799 hasPublicationYear "2012" @default.
• W1980798799 type Work @default.
• W1980798799 sameAs 1980798799 @default.
• W1980798799 citedByCount "19" @default.
• W1980798799 countsByYear W19807987992012 @default.
• W1980798799 countsByYear W19807987992014 @default.
• W1980798799 countsByYear W19807987992015 @default.
• W1980798799 countsByYear W19807987992016 @default.
• W1980798799 countsByYear W19807987992017 @default.
• W1980798799 countsByYear W19807987992018 @default.
• W1980798799 countsByYear W19807987992019 @default.
• W1980798799 countsByYear W19807987992020 @default.
• W1980798799 countsByYear W19807987992021 @default.
• W1980798799 countsByYear W19807987992023 @default.
• W1980798799 crossrefType "journal-article" @default.
• W1980798799 hasAuthorship W1980798799A5016822440 @default.
• W1980798799 hasAuthorship W1980798799A5043108427 @default.
• W1980798799 hasAuthorship W1980798799A5062939937 @default.

• next