Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980825419> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1980825419 abstract "Few studies have evaluated lymph node metastasis in African-American (AA) women with breast cancer, who are more likely to be diagnosed at an advanced stage and with lymph node positive tumors. Likelihood of nodal involvement increases with tumor size, although recent data have indicated that this may not be true for AA breast cancer patients and patients with basal-like tumors. Nodal metastases are also more likely in premenopausal AA patients compared to either premenopausal European-American (EA) patients or postmenopausal AA and EA patients. We examined risk factors for lymph node metastasis at breast cancer diagnosis in AA and EA women, and investigated the contributions of race, tumor subtype, and menopausal status to the tumor size-lymph node metastasis relationship. This analysis included 805 women diagnosed with primary, incident breast cancer enrolled in the Women9s Circle of Health Study, a case-control study of AA and EA breast cancer patients and healthy women. Cases were identified using hospital-based ascertainment in New York City hospitals with high referral patterns for AA women and through population-based ascertainment in New Jersey using the State Cancer Registry. Eligible cases were self-identified AA and EA women age 20-75 with no previous history of cancer other than nonmelanoma skin cancer. In-person interviews were conducted and consent to review pathology reports was obtained. Tumor size was categorized as tumors 2 cm or less (small tumors) and tumors greater than 2 cm (large tumors). Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). AAs with small tumors were more likely to be node positive compared to EAs (OR=1.24, 95% CI 0.81-1.88) while among patients with large tumors, AAs were less likely to be node positive (OR=0.83, 95% CI 0.49-1.41). When grouped by race and tumor subtype, we found that the triple negative subtype was associated with a decreased risk of nodal metastases among EA women with small tumors (OR=0.17, 95% CI 0.04-0.79) and a nonsignificantly decreased risk among AA women with large tumors, using the luminal A subtype as the referent group. Associations were null in EA women with large tumors and AA women with small tumors. When grouped by race and ER status, ER negativity was associated with a decreased risk of nodal metastases among AA women with large tumors (OR=0.41, 95% CI 0.20-0.84), while AA women with small tumors were at increased risk (OR=1.90, 95% CI 0.92-3.91). Our data suggest an effect of race and tumor subtype on the relationship between tumor size and likelihood of lymph node metastases. Tumor size appears to affect lymph node metastasis differently by race, a mechanism that is modified by tumor biology. Our findings support the hypothesis that in AA breast cancer patients, large tumors may not be more likely to give rise to metastatic lymph nodes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3593. doi:1538-7445.AM2012-3593" @default.
- W1980825419 created "2016-06-24" @default.
- W1980825419 creator A5003277934 @default.
- W1980825419 creator A5015171893 @default.
- W1980825419 creator A5026463096 @default.
- W1980825419 creator A5030647280 @default.
- W1980825419 creator A5036294770 @default.
- W1980825419 creator A5056927935 @default.
- W1980825419 creator A5072404388 @default.
- W1980825419 creator A5072498226 @default.
- W1980825419 creator A5081202262 @default.
- W1980825419 creator A5084538612 @default.
- W1980825419 creator A5091439429 @default.
- W1980825419 date "2012-04-15" @default.
- W1980825419 modified "2023-10-01" @default.
- W1980825419 title "Abstract 3593: Tumor size and lymph node metastases in African-American and European-American women with breast cancer" @default.
- W1980825419 doi "https://doi.org/10.1158/1538-7445.am2012-3593" @default.
- W1980825419 hasPublicationYear "2012" @default.
- W1980825419 type Work @default.
- W1980825419 sameAs 1980825419 @default.
- W1980825419 citedByCount "5" @default.
- W1980825419 countsByYear W19808254192017 @default.
- W1980825419 countsByYear W19808254192020 @default.
- W1980825419 countsByYear W19808254192021 @default.
- W1980825419 crossrefType "proceedings-article" @default.
- W1980825419 hasAuthorship W1980825419A5003277934 @default.
- W1980825419 hasAuthorship W1980825419A5015171893 @default.
- W1980825419 hasAuthorship W1980825419A5026463096 @default.
- W1980825419 hasAuthorship W1980825419A5030647280 @default.
- W1980825419 hasAuthorship W1980825419A5036294770 @default.
- W1980825419 hasAuthorship W1980825419A5056927935 @default.
- W1980825419 hasAuthorship W1980825419A5072404388 @default.
- W1980825419 hasAuthorship W1980825419A5072498226 @default.
- W1980825419 hasAuthorship W1980825419A5081202262 @default.
- W1980825419 hasAuthorship W1980825419A5084538612 @default.
- W1980825419 hasAuthorship W1980825419A5091439429 @default.
- W1980825419 hasConcept C121608353 @default.
- W1980825419 hasConcept C126322002 @default.
- W1980825419 hasConcept C143998085 @default.
- W1980825419 hasConcept C156957248 @default.
- W1980825419 hasConcept C2779013556 @default.
- W1980825419 hasConcept C2780849966 @default.
- W1980825419 hasConcept C2908647359 @default.
- W1980825419 hasConcept C29456083 @default.
- W1980825419 hasConcept C530470458 @default.
- W1980825419 hasConcept C71924100 @default.
- W1980825419 hasConcept C99454951 @default.
- W1980825419 hasConceptScore W1980825419C121608353 @default.
- W1980825419 hasConceptScore W1980825419C126322002 @default.
- W1980825419 hasConceptScore W1980825419C143998085 @default.
- W1980825419 hasConceptScore W1980825419C156957248 @default.
- W1980825419 hasConceptScore W1980825419C2779013556 @default.
- W1980825419 hasConceptScore W1980825419C2780849966 @default.
- W1980825419 hasConceptScore W1980825419C2908647359 @default.
- W1980825419 hasConceptScore W1980825419C29456083 @default.
- W1980825419 hasConceptScore W1980825419C530470458 @default.
- W1980825419 hasConceptScore W1980825419C71924100 @default.
- W1980825419 hasConceptScore W1980825419C99454951 @default.
- W1980825419 hasLocation W19808254191 @default.
- W1980825419 hasOpenAccess W1980825419 @default.
- W1980825419 hasPrimaryLocation W19808254191 @default.
- W1980825419 hasRelatedWork W1169589700 @default.
- W1980825419 hasRelatedWork W17538324 @default.
- W1980825419 hasRelatedWork W1965225327 @default.
- W1980825419 hasRelatedWork W1965642386 @default.
- W1980825419 hasRelatedWork W1966562076 @default.
- W1980825419 hasRelatedWork W1977079905 @default.
- W1980825419 hasRelatedWork W1990789818 @default.
- W1980825419 hasRelatedWork W2007540402 @default.
- W1980825419 hasRelatedWork W2105624671 @default.
- W1980825419 hasRelatedWork W2161187032 @default.
- W1980825419 hasRelatedWork W2226017319 @default.
- W1980825419 hasRelatedWork W2316152431 @default.
- W1980825419 hasRelatedWork W2317141689 @default.
- W1980825419 hasRelatedWork W2328821200 @default.
- W1980825419 hasRelatedWork W2588889579 @default.
- W1980825419 hasRelatedWork W2621449981 @default.
- W1980825419 hasRelatedWork W2967059949 @default.
- W1980825419 hasRelatedWork W3138715053 @default.
- W1980825419 hasRelatedWork W3204590366 @default.
- W1980825419 hasRelatedWork W2510391956 @default.
- W1980825419 isParatext "false" @default.
- W1980825419 isRetracted "false" @default.
- W1980825419 magId "1980825419" @default.
- W1980825419 workType "article" @default.