FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980830278> ?p ?o ?g. }

• W1980830278 endingPage "745" @default.
• W1980830278 startingPage "740" @default.
• W1980830278 abstract "Endothelial cell migration and proliferation are the key steps in the angiogenic process, and both are stimulated by recombinant human erythropoietin (rHuEPO). In addition rHuEPO can increase endothelin-1 (ET-1) release by the endothelial cell. We designed the present study to address the question of whether rHuEPO stimulates angiogenesis. An in vitro quantitative assay for angiogenesis was used. This consisted of rat aortic rings embedded in a reconstituted basement membrane matrix and incubated with and without rHuEPO for eight days. We found that rHuEPO increased vessel outgrowth after four days of culture and this was continued for the next four days (rHuEPO vs. control: day 4, 12 +/- 2 vs. 4 +/- 1, P < 0.002 and day 8, 124 +/- 18 vs. 56 +/- 12 P < 0.006). Supernatant endothelin-1 (ET-1) levels, at 24 hours, were significantly higher than controls in the rings incubated with rHuEPO (107 +/- 13 vs. 43 +/- 10 pg/ml, P < 0.003). To investigate the role of ET-1 in rHuEPO-induced angiogenesis, rings were exposed to ET-1 alone (10(-8) M). We observed an increase in microvessel formation compared to control (day 4, 4 +/- 2 vs. 2 +/- 1, P < 0.006, and day 8, 67 +/- 12 vs. 51 +/- 10, P < 0.03). In addition, aortic rings were co-cultured with rHuEPO and anti-ET-1 IgG antibody. Stimulation of angiogenesis by rHuEPO was blunted by the ET-1 antibody.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W1980830278 created "2016-06-24" @default.
• W1980830278 creator A5005797101 @default.
• W1980830278 creator A5028270795 @default.
• W1980830278 creator A5034571964 @default.
• W1980830278 date "1995-03-01" @default.
• W1980830278 modified "2023-10-15" @default.
• W1980830278 title "Recombinant human erythropoietin stimulates angiogenesis in vitro" @default.
• W1980830278 cites W1948194396 @default.
• W1980830278 cites W1968498453 @default.
• W1980830278 cites W2017606827 @default.
• W1980830278 cites W2019819590 @default.
• W1980830278 cites W2024986103 @default.
• W1980830278 cites W2025908951 @default.
• W1980830278 cites W2035047456 @default.
• W1980830278 cites W2043353719 @default.
• W1980830278 cites W2051458931 @default.
• W1980830278 cites W2056966654 @default.
• W1980830278 cites W2057576736 @default.
• W1980830278 cites W2077389282 @default.
• W1980830278 cites W2078120099 @default.
• W1980830278 cites W2088860530 @default.
• W1980830278 cites W2134582008 @default.
• W1980830278 cites W2155348627 @default.
• W1980830278 cites W2313239162 @default.
• W1980830278 cites W2315329949 @default.
• W1980830278 cites W2341398312 @default.
• W1980830278 cites W2407717752 @default.
• W1980830278 cites W4245172576 @default.
• W1980830278 doi "https://doi.org/10.1038/ki.1995.113" @default.
• W1980830278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7752572" @default.
• W1980830278 hasPublicationYear "1995" @default.
• W1980830278 type Work @default.
• W1980830278 sameAs 1980830278 @default.
• W1980830278 citedByCount "241" @default.
• W1980830278 countsByYear W19808302782012 @default.
• W1980830278 countsByYear W19808302782013 @default.
• W1980830278 countsByYear W19808302782014 @default.
• W1980830278 countsByYear W19808302782015 @default.
• W1980830278 countsByYear W19808302782016 @default.
• W1980830278 countsByYear W19808302782017 @default.
• W1980830278 countsByYear W19808302782018 @default.
• W1980830278 countsByYear W19808302782019 @default.
• W1980830278 countsByYear W19808302782021 @default.
• W1980830278 countsByYear W19808302782022 @default.
• W1980830278 countsByYear W19808302782023 @default.
• W1980830278 crossrefType "journal-article" @default.
• W1980830278 hasAuthorship W1980830278A5005797101 @default.
• W1980830278 hasAuthorship W1980830278A5028270795 @default.
• W1980830278 hasAuthorship W1980830278A5034571964 @default.
• W1980830278 hasBestOaLocation W19808302781 @default.
• W1980830278 hasConcept C104317684 @default.
• W1980830278 hasConcept C123012128 @default.
• W1980830278 hasConcept C126322002 @default.
• W1980830278 hasConcept C134018914 @default.
• W1980830278 hasConcept C142724271 @default.
• W1980830278 hasConcept C149601957 @default.
• W1980830278 hasConcept C16685009 @default.
• W1980830278 hasConcept C170493617 @default.
• W1980830278 hasConcept C202751555 @default.
• W1980830278 hasConcept C203014093 @default.
• W1980830278 hasConcept C24998067 @default.
• W1980830278 hasConcept C2776193487 @default.
• W1980830278 hasConcept C2776436680 @default.
• W1980830278 hasConcept C2778271429 @default.
• W1980830278 hasConcept C2778534260 @default.
• W1980830278 hasConcept C2780394083 @default.
• W1980830278 hasConcept C40767141 @default.
• W1980830278 hasConcept C55493867 @default.
• W1980830278 hasConcept C71924100 @default.
• W1980830278 hasConcept C86803240 @default.
• W1980830278 hasConceptScore W1980830278C104317684 @default.
• W1980830278 hasConceptScore W1980830278C123012128 @default.
• W1980830278 hasConceptScore W1980830278C126322002 @default.
• W1980830278 hasConceptScore W1980830278C134018914 @default.
• W1980830278 hasConceptScore W1980830278C142724271 @default.
• W1980830278 hasConceptScore W1980830278C149601957 @default.
• W1980830278 hasConceptScore W1980830278C16685009 @default.
• W1980830278 hasConceptScore W1980830278C170493617 @default.
• W1980830278 hasConceptScore W1980830278C202751555 @default.
• W1980830278 hasConceptScore W1980830278C203014093 @default.
• W1980830278 hasConceptScore W1980830278C24998067 @default.
• W1980830278 hasConceptScore W1980830278C2776193487 @default.
• W1980830278 hasConceptScore W1980830278C2776436680 @default.
• W1980830278 hasConceptScore W1980830278C2778271429 @default.
• W1980830278 hasConceptScore W1980830278C2778534260 @default.
• W1980830278 hasConceptScore W1980830278C2780394083 @default.
• W1980830278 hasConceptScore W1980830278C40767141 @default.
• W1980830278 hasConceptScore W1980830278C55493867 @default.
• W1980830278 hasConceptScore W1980830278C71924100 @default.
• W1980830278 hasConceptScore W1980830278C86803240 @default.
• W1980830278 hasIssue "3" @default.
• W1980830278 hasLocation W19808302781 @default.
• W1980830278 hasLocation W19808302782 @default.
• W1980830278 hasOpenAccess W1980830278 @default.
• W1980830278 hasPrimaryLocation W19808302781 @default.
• W1980830278 hasRelatedWork W1588725841 @default.
• W1980830278 hasRelatedWork W2002131026 @default.

• next