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- W1980830876 abstract "The overflow of endogenous noradrenaline from the isolated rat tail artery was measured using a radioenzymatic method. Veratridine increased the overflow markedly even in the absence of external Ca2+. Modifications of the effect of 5 microM veratridine by tetrodotoxin, pargyline, cocaine, lidocaine, and phenoxybenzamine indicated that interaction of the alkaloid with the sodium channel induces primarily nonexocytotic release of noradrenaline. Ouabain inhibited the effect of 5 microM veratridine on the overflow into Ca2+-free solution, but it greatly potentiated the effect if external Ca2+ was present. Potentiation of the effect of veratridine in Ca2+-free solution by cyanide was ouabain sensitive. These observations are consistent with the hypothesis that, at low concentrations of veratridine such as 5 microM, the initial cause of enhanced release of noradrenaline may be a consequence of increased activity of the sodium pump, namely increased consumption of ATP by the pump." @default.
- W1980830876 created "2016-06-24" @default.
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- W1980830876 date "1982-06-01" @default.
- W1980830876 modified "2023-09-26" @default.
- W1980830876 title "Release of endogenous noradrenaline from the rat tail artery induced by veratridine" @default.
- W1980830876 doi "https://doi.org/10.1139/y82-112" @default.
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