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- W198084864 abstract "Two substrains of EBV have been defined by biological and biochemical studies. Virus derived from the B-95–8 cell line can immortalize normal B cells. The virus from P3HR-1 cell line induces neither EBNA nor immortalizes normal B cells. In contrast, P3HR-1 virus induces early antigen synthesis in superinfected Raji and NC37 cell lines. Cell lines infected with these different EBV strains also differ in the expression of EBNA antigens. The B 95–8 cell line and cells infected with virus derived from this cell line express a 78 Kd EBNA 1 protein and also EBNA 2. The P3HR-1 cell line express a 74 Kd EBNA 1 protein and does not express EBNA 2 since the gene coding for this protein is deleted in the viral genome. The transformation capability of EBV has been assigned to this gene. It has been reported that coinfection of B cells with B-95–8 and P3HR-1 virus can suppress EBNA 1 expression and immortalization (Steinitz et al., 1978). However, no studies have been made on the effect of coinfection of Raji or NC 37 cell lines.KeywordsVirus Infected CellRaji CellEarly AntigenTransformation CapabilityRaji Cell LineThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W198084864 date "1987-01-01" @default.
- W198084864 modified "2023-09-27" @default.
- W198084864 title "Characterization of the Suppressor Effect of B-95–8 Virus on EA Inducing Capability of P3HR-1 Virus" @default.
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- W198084864 doi "https://doi.org/10.1007/978-1-4612-4590-2_66" @default.
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