Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980855728> ?p ?o ?g. }
- W1980855728 endingPage "4054" @default.
- W1980855728 startingPage "4052" @default.
- W1980855728 abstract "Two privileged drug scaffolds have been hybridized to create the novel heteromorphic nucleoside 5-(2-amino-3-cyano-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)-1-(2-deoxypentofuranosyl)pyrimidine-2,4(1H,3H)-dione (2). Compound 2 inhibited the replication of two orthopoxviruses, vaccinia virus (VV) (EC(50) = 4.6 +/- 2.0 microM), and cowpox virus (CV) (EC(50) = 2.0 +/- 0.3 microM). Compound 2 exhibited reduced activity against a thymidine kinase (TK) negative strain of CV, implying a requirement for 5'-monophosphorylation for antiorthopoxvirus activity. Compound 2 was efficiently phosphorylated by VV TK, establishing that VV TK is more promiscuous than previously believed." @default.
- W1980855728 created "2016-06-24" @default.
- W1980855728 creator A5011161706 @default.
- W1980855728 creator A5015242485 @default.
- W1980855728 creator A5043966211 @default.
- W1980855728 creator A5045032962 @default.
- W1980855728 creator A5075818298 @default.
- W1980855728 creator A5082203681 @default.
- W1980855728 creator A5089341848 @default.
- W1980855728 date "2006-06-17" @default.
- W1980855728 modified "2023-09-27" @default.
- W1980855728 title "Toward Orthopoxvirus Countermeasures: A Novel Heteromorphic Nucleoside of Unusual Structure" @default.
- W1980855728 cites W1545962383 @default.
- W1980855728 cites W1571604632 @default.
- W1980855728 cites W1590495238 @default.
- W1980855728 cites W1964419482 @default.
- W1980855728 cites W1974599773 @default.
- W1980855728 cites W1981587794 @default.
- W1980855728 cites W1982015427 @default.
- W1980855728 cites W1984604346 @default.
- W1980855728 cites W1996617715 @default.
- W1980855728 cites W1999310424 @default.
- W1980855728 cites W2006281337 @default.
- W1980855728 cites W2008283091 @default.
- W1980855728 cites W2019835468 @default.
- W1980855728 cites W2025896059 @default.
- W1980855728 cites W2037801005 @default.
- W1980855728 cites W2038912019 @default.
- W1980855728 cites W2041882259 @default.
- W1980855728 cites W2043915372 @default.
- W1980855728 cites W2045299744 @default.
- W1980855728 cites W2072494909 @default.
- W1980855728 cites W2076093115 @default.
- W1980855728 cites W2079835503 @default.
- W1980855728 cites W2088141646 @default.
- W1980855728 cites W2089303091 @default.
- W1980855728 cites W2109121566 @default.
- W1980855728 cites W2109160175 @default.
- W1980855728 cites W2111822094 @default.
- W1980855728 cites W2111986931 @default.
- W1980855728 cites W2117739721 @default.
- W1980855728 cites W2122072514 @default.
- W1980855728 cites W2130213708 @default.
- W1980855728 cites W2136561168 @default.
- W1980855728 cites W2141571768 @default.
- W1980855728 cites W2144190525 @default.
- W1980855728 cites W2160080080 @default.
- W1980855728 cites W2166079803 @default.
- W1980855728 cites W2172246859 @default.
- W1980855728 cites W2173302446 @default.
- W1980855728 cites W2176863003 @default.
- W1980855728 cites W2330561030 @default.
- W1980855728 cites W2399117155 @default.
- W1980855728 cites W2506757049 @default.
- W1980855728 cites W2952823995 @default.
- W1980855728 cites W4231055449 @default.
- W1980855728 doi "https://doi.org/10.1021/jm060404n" @default.
- W1980855728 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4298854" @default.
- W1980855728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16821766" @default.
- W1980855728 hasPublicationYear "2006" @default.
- W1980855728 type Work @default.
- W1980855728 sameAs 1980855728 @default.
- W1980855728 citedByCount "41" @default.
- W1980855728 countsByYear W19808557282012 @default.
- W1980855728 countsByYear W19808557282013 @default.
- W1980855728 countsByYear W19808557282014 @default.
- W1980855728 countsByYear W19808557282015 @default.
- W1980855728 countsByYear W19808557282016 @default.
- W1980855728 countsByYear W19808557282019 @default.
- W1980855728 countsByYear W19808557282020 @default.
- W1980855728 countsByYear W19808557282022 @default.
- W1980855728 countsByYear W19808557282023 @default.
- W1980855728 crossrefType "journal-article" @default.
- W1980855728 hasAuthorship W1980855728A5011161706 @default.
- W1980855728 hasAuthorship W1980855728A5015242485 @default.
- W1980855728 hasAuthorship W1980855728A5043966211 @default.
- W1980855728 hasAuthorship W1980855728A5045032962 @default.
- W1980855728 hasAuthorship W1980855728A5075818298 @default.
- W1980855728 hasAuthorship W1980855728A5082203681 @default.
- W1980855728 hasAuthorship W1980855728A5089341848 @default.
- W1980855728 hasBestOaLocation W19808557282 @default.
- W1980855728 hasConcept C104317684 @default.
- W1980855728 hasConcept C153911025 @default.
- W1980855728 hasConcept C159047783 @default.
- W1980855728 hasConcept C185592680 @default.
- W1980855728 hasConcept C202751555 @default.
- W1980855728 hasConcept C2522874641 @default.
- W1980855728 hasConcept C2776147627 @default.
- W1980855728 hasConcept C2776543447 @default.
- W1980855728 hasConcept C2777108182 @default.
- W1980855728 hasConcept C2779094796 @default.
- W1980855728 hasConcept C2779321679 @default.
- W1980855728 hasConcept C2779827044 @default.
- W1980855728 hasConcept C2781196997 @default.
- W1980855728 hasConcept C2781356689 @default.
- W1980855728 hasConcept C2908583973 @default.
- W1980855728 hasConcept C40767141 @default.
- W1980855728 hasConcept C55493867 @default.