Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980857624> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W1980857624 abstract "Curcumin (diferuloylmethane) a major component of the Curcuma species, used as a colouring and flavouring agent in foods, is a natural product well known for its antioxidative and anti-inflammatory properties as well as its anticancer potential [1]. It is well established that curcumin is rapidly and extensively metabolized. However it is crucial to understand its metabolism for the design of more stable/potent analogues. In this study we present a set of novel approaches for the identification of curcumin's metabolites following incubation with mouse and human liver microsomes, using a hybrid triple quadrupole linear ion trap mass spectrometer coupled with an HPLC system. Using the system's Information-Dependent Acquisition (IDA) feature allowed us to perform two or more scan modes in the same chromatographic run and in addition selective modes such as MS/MS/MS, enabled us to identify with confidence previously reported metabolites as well as newly identified ones, such as bisglucuronide and O-demethylated derivatives. The information acquired in this study lead to the proposal of a metabolic scheme for curcumin [2]. The same methodology has also been applied to curcumin's analogues with more promising anticancer activity and the results show that such analogues are metabolically significantly more stable than curcumin [3]. Finally, similar approaches have been extended to include other bioactive natural products that potentially play a role in the treatment of cancer, such as indirubin analogues." @default.
- W1980857624 created "2016-06-24" @default.
- W1980857624 creator A5008616806 @default.
- W1980857624 creator A5009213882 @default.
- W1980857624 creator A5044878059 @default.
- W1980857624 creator A5045885042 @default.
- W1980857624 date "2008-07-01" @default.
- W1980857624 modified "2023-09-25" @default.
- W1980857624 title "Novel LC-MS/MS approaches for metabolite identification of natural compounds, such as curcumin and analogues, with anticancer activity" @default.
- W1980857624 doi "https://doi.org/10.1055/s-0028-1083938" @default.
- W1980857624 hasPublicationYear "2008" @default.
- W1980857624 type Work @default.
- W1980857624 sameAs 1980857624 @default.
- W1980857624 citedByCount "0" @default.
- W1980857624 crossrefType "journal-article" @default.
- W1980857624 hasAuthorship W1980857624A5008616806 @default.
- W1980857624 hasAuthorship W1980857624A5009213882 @default.
- W1980857624 hasAuthorship W1980857624A5044878059 @default.
- W1980857624 hasAuthorship W1980857624A5045885042 @default.
- W1980857624 hasConcept C185592680 @default.
- W1980857624 hasConcept C21565614 @default.
- W1980857624 hasConcept C21951064 @default.
- W1980857624 hasConcept C2777230291 @default.
- W1980857624 hasConcept C2777477808 @default.
- W1980857624 hasConcept C2778250585 @default.
- W1980857624 hasConcept C2779396153 @default.
- W1980857624 hasConcept C43617362 @default.
- W1980857624 hasConcept C55493867 @default.
- W1980857624 hasConcept C556039675 @default.
- W1980857624 hasConcept C71924100 @default.
- W1980857624 hasConcept C86803240 @default.
- W1980857624 hasConcept C98274493 @default.
- W1980857624 hasConceptScore W1980857624C185592680 @default.
- W1980857624 hasConceptScore W1980857624C21565614 @default.
- W1980857624 hasConceptScore W1980857624C21951064 @default.
- W1980857624 hasConceptScore W1980857624C2777230291 @default.
- W1980857624 hasConceptScore W1980857624C2777477808 @default.
- W1980857624 hasConceptScore W1980857624C2778250585 @default.
- W1980857624 hasConceptScore W1980857624C2779396153 @default.
- W1980857624 hasConceptScore W1980857624C43617362 @default.
- W1980857624 hasConceptScore W1980857624C55493867 @default.
- W1980857624 hasConceptScore W1980857624C556039675 @default.
- W1980857624 hasConceptScore W1980857624C71924100 @default.
- W1980857624 hasConceptScore W1980857624C86803240 @default.
- W1980857624 hasConceptScore W1980857624C98274493 @default.
- W1980857624 hasIssue "09" @default.
- W1980857624 hasLocation W19808576241 @default.
- W1980857624 hasOpenAccess W1980857624 @default.
- W1980857624 hasPrimaryLocation W19808576241 @default.
- W1980857624 hasRelatedWork W2035308484 @default.
- W1980857624 hasRelatedWork W2147047346 @default.
- W1980857624 hasRelatedWork W2167779937 @default.
- W1980857624 hasRelatedWork W2335011010 @default.
- W1980857624 hasRelatedWork W2902380624 @default.
- W1980857624 hasRelatedWork W2954392311 @default.
- W1980857624 hasRelatedWork W2960698964 @default.
- W1980857624 hasRelatedWork W2999697560 @default.
- W1980857624 hasRelatedWork W3135727723 @default.
- W1980857624 hasRelatedWork W2166421510 @default.
- W1980857624 hasVolume "74" @default.
- W1980857624 isParatext "false" @default.
- W1980857624 isRetracted "false" @default.
- W1980857624 magId "1980857624" @default.
- W1980857624 workType "article" @default.