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- W1980862751 abstract "Reactions involving phenol derivatives and acyl chlorides have to be controlled for competitive O-acylations and C-acylations (Friedel–Crafts acylations and Fries rearrangements) in acidic condition. The extent for these reactions in trifluoromethanesulfonic acid (TfOH), which is used as catalyst and solvent, is examined. Although diluted TfOH was needed for effective O-acylation, concentrated TfOH was required for effective C-acylations in mild condition. These results have been applied to the novel synthesis of homotyrosine derivatives. Both Fries rearrangement of N-TFA–Asp(OBn)–OMe and Friedel–Crafts acylation of phenol with N-TFA–Asp(Cl)–OMe in TfOH afforded the homotyrosine skeleton, followed by reduction and deprotection afforded homotyrosines maintaining stereochemistry of Asp as an optically pure form." @default.
- W1980862751 created "2016-06-24" @default.
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- W1980862751 date "2011-01-01" @default.
- W1980862751 modified "2023-10-15" @default.
- W1980862751 title "Comparisons of O-acylation and Friedel–Crafts acylation of phenols and acyl chlorides and Fries rearrangement of phenyl esters in trifluoromethanesulfonic acid: effective synthesis of optically active homotyrosines" @default.
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- W1980862751 doi "https://doi.org/10.1016/j.tet.2010.11.047" @default.
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