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• W1980864184 abstract "The discovery of the metal salen-catalyzed asymmetric ring-opening (ARO) of epoxides is chronicled. A screening approach was adopted for the identification of catalysts for the addition of TMSN(3) to meso-epoxides, and the chiral (salen)CrN(3) complex was identified as optimal. Kinetic and structural studies served to elucidate the mechanism of catalysis, which involves cooperative activation of both epoxide and azide by two different metal centers. Covalently linked bimetallic complexes were constructed on the basis of this insight, and shown to catalyze the ARO with identical enantioselectivity but 1-2 orders of magnitude greater reactivity than the monomeric analogues. Extraordinarily high selectivity is observed in the kinetic resolution of terminal epoxides using the (salen)CrN(3)/TMSN(3) system. A search for a practical method for the kinetic resolution reaction led to the discovery of highly enantiomer-selective hydrolytic ring-opening using the corresponding (salen)Co(III) catalyst. This system displays extraordinary substrate generality, and allows practical access to enantiopure terminal epoxides on both laboratory and industrial scales." @default.
• W1980864184 created "2016-06-24" @default.
• W1980864184 creator A5037736695 @default.
• W1980864184 date "2000-05-16" @default.
• W1980864184 modified "2023-10-14" @default.
• W1980864184 title "Asymmetric Catalysis of Epoxide Ring-Opening Reactions" @default.
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• W1980864184 doi "https://doi.org/10.1021/ar960061v" @default.
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