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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980883669> ?p ?o ?g. }

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• W1980883669 abstract "In our laboratory, a series of antimicrobial peptides have been developed, where the resulting 3D-physicochemical properties are controlled by the placement of amino acids with well-defined properties (hydrophobicity, charge density, electrostatic potential, and so on) at specific locations along the peptide backbone. These peptides exhibited different in vitro activity against Staphylococcus aureus (SA) and Mycobacterium ranae (MR) bacteria. We hypothesized that the differences in the biological activity is a direct manifestation of different physicochemical interactions that occur between the peptides and the cell membranes of the bacteria. 3D-QSAR analysis has shown that, within this series, specific physicochemical properties are responsible for antibacterial activity and selectivity. There are five physicochemical properties specific to the SA QSAR model, while five properties are specific to the MR QSAR model. These results support the hypothesis that, for any particular AMP, organism selectivity and potency are controlled by the chemical composition of the target cell membrane." @default.
• W1980883669 created "2016-06-24" @default.
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• W1980883669 date "2007-12-07" @default.
• W1980883669 modified "2023-10-10" @default.
• W1980883669 title "Application of 3D-QSAR for Identification of Descriptors Defining Bioactivity of Antimicrobial Peptides" @default.
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• W1980883669 doi "https://doi.org/10.1021/jm070884y" @default.
• W1980883669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18062663" @default.
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