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• W1980888912 abstract "CD4 T cell lineages are marked by the signature transcription factor each lineage expresses. For example, regulatory T cells (Tregs) are characterized by expression of FOXP3, which is either induced during thymic development for natural Tregs (nTregs), or in the periphery in the presence of TGF-beta and retinoic acid for induced Tregs (iTreg). Interestingly, recent work has shown that the signature transcription factor for Th17 cells, RORgammat, is also induced by TGF-beta, thus linking the differentiation of the Treg and Th17 lineages. In the absence of a second signal from a proinflammatory cytokine, FOXP3 can inhibit RORgammat function and drive Treg differentiation. However, when the cell also receives a signal from a proinflammation cytokine (e.g., IL-6), FOXP3 function is inhibited and the Th17 differentiation pathway is induced. Therefore, it is the balance between FOXP3 and RORgammat function that determines CD4 T cell fate and the type of immune response that will be generated." @default.
• W1980888912 created "2016-06-24" @default.
• W1980888912 creator A5019862484 @default.
• W1980888912 creator A5050390918 @default.
• W1980888912 date "2009-04-01" @default.
• W1980888912 modified "2023-09-26" @default.
• W1980888912 title "FOXP3 and the regulation of Treg/Th17 differentiation" @default.
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• W1980888912 doi "https://doi.org/10.1016/j.micinf.2009.04.002" @default.
• W1980888912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2728495" @default.
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