FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980888931> ?p ?o ?g. }

• W1980888931 abstract "·ivikova K. , J . Dianovsk : Mitotic Index and Cell Proliferation Kinetics as Additional Variables for Assessment of Genotoxic Effect of The Herbicide Modown. Acta Vet. Brno 2000, 69: 45–50. The in vitro effect of the herbicide Modown (with active component bifenox) was tested for the ability to influence cell proliferation of PHA-stimulated bovine peripheral lymphocytes. Mitotic (MI) and proliferation (PI) indices were determined as an alternative for the screening of the cytostatic activity. The herbicide Modown exerted a clear effect on the inhibition of MI and PI over a concentration-tested range of 25 μg/ml to 1000 μg/ml. An expressive proliferation delays was found after the treatment with herbicide at a dose of 250 μg/ml (P < 0.001), while the higher doses of 500 and 1000 μg/ml had caused nearly complete mitotic inhibition in each donor (P < 0.05 and P < 0.001, respectively). A correlation between the PI and MI inhibition refers rather to cytostatic than cytotoxic effects of the herbicide. The results support the possibility of immunosuppression by herbicide exposure. Herbicide Modown, bovine peripheral lymphocytes, cell proliferation, cytostatic effect Nitrodiphenylether herbicides are persistent and lipophilic environmental contaminants may contribute to the impairment of animal health and production. The presence of pesticide residues has been demonstrated in raw bovine milk and in different domestic animal tissues (Lioi et al. 1998). All nitrodiphenylether herbicides exert their phytotoxic activity in chlorophyll of plants by the reduction itself to radical species, which initiate destructive reactions in membrane lipids, leading to the cell leakage (Corbet t et al. 1984). Members, as acifluorfen and oxyfluorfen, e.g. are extremely potent inhibitors of protoporphyrinogen oxidase, a membrane–bound enzyme involved in the heme and chlorophyll biosynthesis pathways (Camadro et al. 1995). The later was studied for the induction of haematological diseases in human erythroid progenitor cells but a cytotoxic effect had been seen only at very high concentrations (Rio et al. 1997). Bifenox is a selective herbicide used in control of annual broad-leaved weeds and some grasses, e. g. in cereals, maize, soya beans, rice and other crops. J inno et al. (1999) described the cytotoxic and porphyrogenic effects of bifenox in rat hepatocytes. They found the maximum porphyrin accumulation at 0.25 mM of the herbicide and an inhibion of protoporphyrogen oxidase, resulting in the accumulation of protoporphyrin IX. Francis et al. (1999) evaluated maternal and developmental toxicity of ten diphenylether herbicides (including bifenox) in mice. They found a correlation among the position of chlorine substituents and the potential for inducing prenatal and postnatal syndroms. But no prenatal and postnatal embryotoxicity was shown. ACTA VET. BRNO 2000, 69: 45–50 Address for correspondence: RNDr. Katarina ·ivikova, CSc. Department of Veterinary Genetics, University of Veterinary Medicine Komenskeho 73, 041 81 Ko‰ice, Slovak Republic Phone: +421 95 63 321 11, (ext. 482) Fax: +421 95 63 236 66 E-mail: sivikova@uvm.sk http://www.vfu.cz/acta-vet/actavet.htm" @default.
• W1980888931 created "2016-06-24" @default.
• W1980888931 creator A5030689649 @default.
• W1980888931 creator A5041193186 @default.
• W1980888931 date "2000-01-01" @default.
• W1980888931 modified "2023-10-05" @default.
• W1980888931 title "Mitotic Index and Cell Proliferation Kinetics as Additional Variables for Assessment of Genotoxic Effect of The Herbicide Modown" @default.
• W1980888931 cites W11870555 @default.
• W1980888931 cites W144860789 @default.
• W1980888931 cites W1978360815 @default.
• W1980888931 cites W1995277333 @default.
• W1980888931 cites W1998981534 @default.
• W1980888931 cites W2010643436 @default.
• W1980888931 cites W2019454076 @default.
• W1980888931 cites W2029841936 @default.
• W1980888931 cites W2033279261 @default.
• W1980888931 cites W2035945483 @default.
• W1980888931 cites W2042780501 @default.
• W1980888931 cites W2079461415 @default.
• W1980888931 cites W2084058766 @default.
• W1980888931 cites W2089028717 @default.
• W1980888931 cites W2090161049 @default.
• W1980888931 cites W2153840630 @default.
• W1980888931 doi "https://doi.org/10.2754/avb200069010045" @default.
• W1980888931 hasPublicationYear "2000" @default.
• W1980888931 type Work @default.
• W1980888931 sameAs 1980888931 @default.
• W1980888931 citedByCount "4" @default.
• W1980888931 countsByYear W19808889312013 @default.
• W1980888931 countsByYear W19808889312023 @default.
• W1980888931 crossrefType "journal-article" @default.
• W1980888931 hasAuthorship W1980888931A5030689649 @default.
• W1980888931 hasAuthorship W1980888931A5041193186 @default.
• W1980888931 hasBestOaLocation W19808889311 @default.
• W1980888931 hasConcept C178790620 @default.
• W1980888931 hasConcept C185592680 @default.
• W1980888931 hasConcept C202751555 @default.
• W1980888931 hasConcept C2910938049 @default.
• W1980888931 hasConcept C29730261 @default.
• W1980888931 hasConcept C55493867 @default.
• W1980888931 hasConcept C62112901 @default.
• W1980888931 hasConcept C66640590 @default.
• W1980888931 hasConcept C86803240 @default.
• W1980888931 hasConcept C93304396 @default.
• W1980888931 hasConcept C95444343 @default.
• W1980888931 hasConcept C98274493 @default.
• W1980888931 hasConceptScore W1980888931C178790620 @default.
• W1980888931 hasConceptScore W1980888931C185592680 @default.
• W1980888931 hasConceptScore W1980888931C202751555 @default.
• W1980888931 hasConceptScore W1980888931C2910938049 @default.
• W1980888931 hasConceptScore W1980888931C29730261 @default.
• W1980888931 hasConceptScore W1980888931C55493867 @default.
• W1980888931 hasConceptScore W1980888931C62112901 @default.
• W1980888931 hasConceptScore W1980888931C66640590 @default.
• W1980888931 hasConceptScore W1980888931C86803240 @default.
• W1980888931 hasConceptScore W1980888931C93304396 @default.
• W1980888931 hasConceptScore W1980888931C95444343 @default.
• W1980888931 hasConceptScore W1980888931C98274493 @default.
• W1980888931 hasLocation W19808889311 @default.
• W1980888931 hasOpenAccess W1980888931 @default.
• W1980888931 hasPrimaryLocation W19808889311 @default.
• W1980888931 hasRelatedWork W1565316635 @default.
• W1980888931 hasRelatedWork W2010556539 @default.
• W1980888931 hasRelatedWork W2025933795 @default.
• W1980888931 hasRelatedWork W2048042371 @default.
• W1980888931 hasRelatedWork W2051140504 @default.
• W1980888931 hasRelatedWork W2052203426 @default.
• W1980888931 hasRelatedWork W2056034615 @default.
• W1980888931 hasRelatedWork W2059511718 @default.
• W1980888931 hasRelatedWork W2074376292 @default.
• W1980888931 hasRelatedWork W2081086225 @default.
• W1980888931 hasRelatedWork W2340868196 @default.
• W1980888931 hasRelatedWork W2412384947 @default.
• W1980888931 hasRelatedWork W2521772214 @default.
• W1980888931 hasRelatedWork W2765189896 @default.
• W1980888931 hasRelatedWork W2768241634 @default.
• W1980888931 hasRelatedWork W2774396886 @default.
• W1980888931 hasRelatedWork W2972918115 @default.
• W1980888931 hasRelatedWork W3048364851 @default.
• W1980888931 hasRelatedWork W3121781868 @default.
• W1980888931 hasRelatedWork W615866954 @default.
• W1980888931 isParatext "false" @default.
• W1980888931 isRetracted "false" @default.
• W1980888931 magId "1980888931" @default.
• W1980888931 workType "article" @default.