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- W1980896714 abstract "Meniscal tears are relatively common injuries sustained by athletes and non-athletes alike and have far reaching functional and financial implications. Studies have clearly demonstrated the important biomechanical role played by the meniscus. Long-term follow-up studies of post-menisectomy patients show a predisposition toward the development of degenerative arthritic changes. As such, substantial efforts have been made by researchers and clinicians to understand the cellular and molecular basis of meniscal healing. Proinflammatory cytokines have been shown to have a catabolic effect on meniscal healing. In vitro and some limited in vivo studies have shown a proliferative and anabolic response to various growth factors. Surgical techniques that have been developed to stimulate a healing response include mechanical abrasion, fibrin clot application, growth factor application, and attempts at meniscal neovascularization. This article discusses various augmentation techniques for meniscal repair and reviews the current literature with regard to fibrin clot, platelet rich plasma, proinflammatory cytokines, and application of growth factors." @default.
- W1980896714 created "2016-06-24" @default.
- W1980896714 creator A5061713279 @default.
- W1980896714 creator A5063311766 @default.
- W1980896714 date "2013-03-13" @default.
- W1980896714 modified "2023-10-18" @default.
- W1980896714 title "Augmentation techniques for isolated meniscal tears" @default.
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- W1980896714 doi "https://doi.org/10.1007/s12178-013-9165-z" @default.
- W1980896714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3702772" @default.
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