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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980906823> ?p ?o ?g. }

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• W1980906823 abstract "Sifuvirtide is a proven effective HIV-1 entry inhibitor and its safety profile has been established for systemic administration. The present study evaluated the potential of sifuvirtide formulated in a universal gel for topical use as a microbicide candidate for preventing sexual transmission of HIV. Our data showed that sifuvirtide formulated in HEC gel is effective against HIV-1 B, C subtypes, CRF07_BC and CRF01_AE, the latter two recombinants represents the most prevalent strains in China. In addition, we demonstrated that sifuvirtide in gel is stable for at least 8 weeks even at 40°C, and did not cause the disruption of integrity of mucosal epithelial surface, or the up-regulation of inflammatory cytokines both in vitro or in vivo. These results suggest that sifuvirtide gel is an effective, safe and stable product, and should be further tested as a vaginal or rectal microbicide in pre-clinical model or clinical trial for preventing HIV sexual transmission." @default.
• W1980906823 created "2016-06-24" @default.
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• W1980906823 date "2012-05-16" @default.
• W1980906823 modified "2023-10-06" @default.
• W1980906823 title "Efficacy, Stability, and Biosafety of Sifuvirtide Gel as a Microbicide Candidate against HIV-1" @default.
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• W1980906823 doi "https://doi.org/10.1371/journal.pone.0037381" @default.
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