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- W1980921198 abstract "To summarize and analyse the published literature on the efficacy and safety of dabigatran for anticoagulation during atrial fibrillation (AF) ablation. A comprehensive search of the literature in the English language was conducted and 10 studies were identified which compared dabigatran therapy with warfarin. Data were extracted and meta-analysed using appropriate methodology. There was significant clinical heterogeneity among studies concerning study designs and methodologies. Most studies consisted of retrospective single-centre observational studies. A total of 3648 patients were included of whom 2241 were receiving warfarin and 1407 dabigatran. Only 12 thrombo-embolic events were reported, 3 during warfarin and 9 during dabigatran therapy [odds ratio (OR) 2.38, 95% confidence interval (CI) 0.82–6.85, P = n.s.). The pooled rate of major bleeding events was similar for warfarin and for dabigatran (OR 1.05, 95% CI 0.62–1.80; P = n.s.). Rates of minor bleeding events were also similar between the two treatment groups. Dabigatran has similar efficacy and safety compared with warfarin when used for periprocedural anticoagulation during AF ablation." @default.
- W1980921198 created "2016-06-24" @default.
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- W1980921198 date "2013-08-16" @default.
- W1980921198 modified "2023-10-07" @default.
- W1980921198 title "Safety and efficacy of dabigatran etexilate during catheter ablation of atrial fibrillation: a meta-analysis of the literature" @default.
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- W1980921198 doi "https://doi.org/10.1093/europace/eut241" @default.
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