FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980921374> ?p ?o ?g. }

• W1980921374 endingPage "e39501" @default.
• W1980921374 startingPage "e39501" @default.
• W1980921374 abstract "The main challenge in addressing the role of DNA methylation in human behaviour is the fact that the brain is inaccessible to epigenetic analysis in living humans. Using positron emission tomography (PET) measures of brain serotonin (5-HT) synthesis, we found in a longitudinal sample that adult males with high childhood-limited aggression (C-LHPA) had lower in vivo 5-HT synthesis in the orbitofrontal cortex (OBFC). Here we hypothesized that 5-HT alterations associated with childhood aggression were linked to differential DNA methylation of critical genes in the 5-HT pathway and these changes were also detectable in peripheral white blood cells. Using pyrosequencing, we determined the state of DNA methylation of SLC6A4 promoter in T cells and monocytes isolated from blood of cohort members (N = 25) who underwent a PET scan, and we examined whether methylation status in the blood is associated with in vivo brain 5-HT synthesis. Higher levels of methylation were observed in both T cells and monocytes at specific CpG sites in the C-LHPA group. DNA methylation of SLC6A4 in monocytes appears to be associated more reliably with group membership than T cells. In both cell types the methylation state of these CpGs was associated with lower in vivo measures of brain 5-HT synthesis in the left and right lateral OBFC (N = 20) where lower 5-HT synthesis in C-LHPA group was observed. Furthermore, in vitro methylation of the SLC6A4 promoter in a luciferase reporter construct suppresses its transcriptional activity supporting a functional role of DNA methylation in SLC6A4 promoter regulation. These findings indicate that state of SLC6A4 promoter methylation is altered in peripheral white blood cells of individuals with physical aggression during childhood. This supports the relevance of peripheral DNA methylation for brain function and suggests that peripheral SLC6A4 DNA methylation could be a marker of central 5-HT function." @default.
• W1980921374 created "2016-06-24" @default.
• W1980921374 creator A5002118289 @default.
• W1980921374 creator A5002601832 @default.
• W1980921374 creator A5005067404 @default.
• W1980921374 creator A5007458839 @default.
• W1980921374 creator A5024259874 @default.
• W1980921374 creator A5033045880 @default.
• W1980921374 creator A5033928968 @default.
• W1980921374 creator A5045833184 @default.
• W1980921374 creator A5056528227 @default.
• W1980921374 creator A5072502595 @default.
• W1980921374 date "2012-06-20" @default.
• W1980921374 modified "2023-10-03" @default.
• W1980921374 title "Peripheral SLC6A4 DNA Methylation Is Associated with In Vivo Measures of Human Brain Serotonin Synthesis and Childhood Physical Aggression" @default.
• W1980921374 cites W1534088620 @default.
• W1980921374 cites W1576611598 @default.
• W1980921374 cites W1628320827 @default.
• W1980921374 cites W1974756082 @default.
• W1980921374 cites W1988816787 @default.
• W1980921374 cites W2005534453 @default.
• W1980921374 cites W2008579533 @default.
• W1980921374 cites W2011812102 @default.
• W1980921374 cites W2014711343 @default.
• W1980921374 cites W2020113570 @default.
• W1980921374 cites W2022452929 @default.
• W1980921374 cites W2023217334 @default.
• W1980921374 cites W2040708659 @default.
• W1980921374 cites W2062276181 @default.
• W1980921374 cites W2064655944 @default.
• W1980921374 cites W2080336014 @default.
• W1980921374 cites W2082289482 @default.
• W1980921374 cites W2082950662 @default.
• W1980921374 cites W2106095564 @default.
• W1980921374 cites W2121417064 @default.
• W1980921374 cites W2124984580 @default.
• W1980921374 cites W2144640180 @default.
• W1980921374 cites W2145152152 @default.
• W1980921374 cites W2146445446 @default.
• W1980921374 cites W2148307692 @default.
• W1980921374 cites W2148337554 @default.
• W1980921374 cites W2151396264 @default.
• W1980921374 cites W2155877766 @default.
• W1980921374 cites W2158647822 @default.
• W1980921374 cites W2167901709 @default.
• W1980921374 cites W2170760271 @default.
• W1980921374 doi "https://doi.org/10.1371/journal.pone.0039501" @default.
• W1980921374 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3379993" @default.
• W1980921374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22745770" @default.
• W1980921374 hasPublicationYear "2012" @default.
• W1980921374 type Work @default.
• W1980921374 sameAs 1980921374 @default.
• W1980921374 citedByCount "174" @default.
• W1980921374 countsByYear W19809213742012 @default.
• W1980921374 countsByYear W19809213742013 @default.
• W1980921374 countsByYear W19809213742014 @default.
• W1980921374 countsByYear W19809213742015 @default.
• W1980921374 countsByYear W19809213742016 @default.
• W1980921374 countsByYear W19809213742017 @default.
• W1980921374 countsByYear W19809213742018 @default.
• W1980921374 countsByYear W19809213742019 @default.
• W1980921374 countsByYear W19809213742020 @default.
• W1980921374 countsByYear W19809213742021 @default.
• W1980921374 countsByYear W19809213742022 @default.
• W1980921374 countsByYear W19809213742023 @default.
• W1980921374 crossrefType "journal-article" @default.
• W1980921374 hasAuthorship W1980921374A5002118289 @default.
• W1980921374 hasAuthorship W1980921374A5002601832 @default.
• W1980921374 hasAuthorship W1980921374A5005067404 @default.
• W1980921374 hasAuthorship W1980921374A5007458839 @default.
• W1980921374 hasAuthorship W1980921374A5024259874 @default.
• W1980921374 hasAuthorship W1980921374A5033045880 @default.
• W1980921374 hasAuthorship W1980921374A5033928968 @default.
• W1980921374 hasAuthorship W1980921374A5045833184 @default.
• W1980921374 hasAuthorship W1980921374A5056528227 @default.
• W1980921374 hasAuthorship W1980921374A5072502595 @default.
• W1980921374 hasBestOaLocation W19809213741 @default.
• W1980921374 hasConcept C104317684 @default.
• W1980921374 hasConcept C140173407 @default.
• W1980921374 hasConcept C150194340 @default.
• W1980921374 hasConcept C153911025 @default.
• W1980921374 hasConcept C170493617 @default.
• W1980921374 hasConcept C190727270 @default.
• W1980921374 hasConcept C2775864247 @default.
• W1980921374 hasConcept C33288867 @default.
• W1980921374 hasConcept C41091548 @default.
• W1980921374 hasConcept C54355233 @default.
• W1980921374 hasConcept C552990157 @default.
• W1980921374 hasConcept C86803240 @default.
• W1980921374 hasConceptScore W1980921374C104317684 @default.
• W1980921374 hasConceptScore W1980921374C140173407 @default.
• W1980921374 hasConceptScore W1980921374C150194340 @default.
• W1980921374 hasConceptScore W1980921374C153911025 @default.
• W1980921374 hasConceptScore W1980921374C170493617 @default.
• W1980921374 hasConceptScore W1980921374C190727270 @default.
• W1980921374 hasConceptScore W1980921374C2775864247 @default.
• W1980921374 hasConceptScore W1980921374C33288867 @default.
• W1980921374 hasConceptScore W1980921374C41091548 @default.

• next