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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980931527> ?p ?o ?g. }

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• W1980931527 abstract "E. coli ribosomes with alterations in S12 leading to streptomycin resistance (SmR), dependence (SmD) and pseudodependence (SmP) were studied with the quench-flow technique. Kinetic changes at the various steps of the elongation cycle were identified. The rate of hydrolysis of GTP in the ternary complex in the ribosomal A-site is decreased drastically in SmD and moderately in SmP in relation to wild-type ribosomes. Addition of streptomycin restores much of the wild-type behaviour. The SmD, SmP and SmR ribosomes have an enhanced GTP-hydrolysis idling reaction on EF-Tu, which is correlated with how aggressive proofreaders these ribosomes are in steady-state assays. We use our in vitro findings to discuss the in vivo physiology of these mutants as well as mechanistic features of E. coli translation." @default.
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• W1980931527 date "1992-04-01" @default.
• W1980931527 modified "2023-09-26" @default.
• W1980931527 title "Kinetic properties of Escherichia coli ribosomes with altered forms of S12" @default.
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• W1980931527 doi "https://doi.org/10.1016/0022-2836(92)90466-w" @default.
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