FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980962718> ?p ?o ?g. }

• W1980962718 endingPage "828" @default.
• W1980962718 startingPage "820" @default.
• W1980962718 abstract "Mammalian megakaryocyte development is characterized by a progressive accumulation of cells exhibiting a polylobated nucleus with a polyploid DNA content. In this study human megakaryocytes were obtained from CD34+ haemopoietic progenitors by in vitro liquid culture in the presence of 100 ng/ml of recombinant thrombopoietin (TPO). Ultrastructural examination of polyploid megakaryocytes showed the presence of a large number of centrioles, the breakdown of the nuclear envelope, and the progressive chromatin condensation, all aspects characteristic of mitosis. At both indirect immunofluorescence and Western blot analyses, cyclin B and its related cyclin-dependent kinase (CDK)1, which forms the mitosis promoting factor (MPF), showed an increased expression in maturating megakaryoblasts and megakaryocytes (day 8 of culture) with respect to freshly isolated CD34+ progenitors. This expression tended to decline in fully developed megakaryocytes (day 15 of culture). The amount of cyclin D and of the related CDK4, governing the G1 phase of the cell cycle, increased during megakaryocyte development, maintaining high levels of expression also in mature megakaryocytes. These results indicate that megakaryocyte polyploidization depends on a true, although incomplete, mitotic process, and that cyclin D/CDK4 probably plays a crucial role throughout megakaryocytopoiesis." @default.
• W1980962718 created "2016-06-24" @default.
• W1980962718 creator A5005222266 @default.
• W1980962718 creator A5028267842 @default.
• W1980962718 creator A5028358932 @default.
• W1980962718 creator A5039533722 @default.
• W1980962718 creator A5066321949 @default.
• W1980962718 creator A5073789933 @default.
• W1980962718 creator A5080771931 @default.
• W1980962718 date "1999-03-01" @default.
• W1980962718 modified "2023-10-17" @default.
• W1980962718 title "Selective modulation of the cyclin B/CDK1 and cyclin D/CDK4 complexes during <i>in vitro</i> human megakaryocyte development" @default.
• W1980962718 cites W11746033 @default.
• W1980962718 cites W1536293876 @default.
• W1980962718 cites W196867602 @default.
• W1980962718 cites W1972474233 @default.
• W1980962718 cites W1980878206 @default.
• W1980962718 cites W199562491 @default.
• W1980962718 cites W2004801261 @default.
• W1980962718 cites W2009946316 @default.
• W1980962718 cites W2020946972 @default.
• W1980962718 cites W2021509469 @default.
• W1980962718 cites W2028988702 @default.
• W1980962718 cites W2047799300 @default.
• W1980962718 cites W2067335007 @default.
• W1980962718 cites W2088511227 @default.
• W1980962718 cites W2089414651 @default.
• W1980962718 cites W2089921110 @default.
• W1980962718 cites W2096956709 @default.
• W1980962718 cites W2171367003 @default.
• W1980962718 cites W2299579214 @default.
• W1980962718 cites W4239520940 @default.
• W1980962718 cites W4245860073 @default.
• W1980962718 cites W4247645508 @default.
• W1980962718 cites W52515759 @default.
• W1980962718 cites W968930547 @default.
• W1980962718 doi "https://doi.org/10.1046/j.1365-2141.1999.01264.x" @default.
• W1980962718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10192445" @default.
• W1980962718 hasPublicationYear "1999" @default.
• W1980962718 type Work @default.
• W1980962718 sameAs 1980962718 @default.
• W1980962718 citedByCount "20" @default.
• W1980962718 countsByYear W19809627182012 @default.
• W1980962718 countsByYear W19809627182013 @default.
• W1980962718 countsByYear W19809627182015 @default.
• W1980962718 countsByYear W19809627182020 @default.
• W1980962718 countsByYear W19809627182021 @default.
• W1980962718 countsByYear W19809627182022 @default.
• W1980962718 crossrefType "journal-article" @default.
• W1980962718 hasAuthorship W1980962718A5005222266 @default.
• W1980962718 hasAuthorship W1980962718A5028267842 @default.
• W1980962718 hasAuthorship W1980962718A5028358932 @default.
• W1980962718 hasAuthorship W1980962718A5039533722 @default.
• W1980962718 hasAuthorship W1980962718A5066321949 @default.
• W1980962718 hasAuthorship W1980962718A5073789933 @default.
• W1980962718 hasAuthorship W1980962718A5080771931 @default.
• W1980962718 hasBestOaLocation W19809627181 @default.
• W1980962718 hasConcept C109159458 @default.
• W1980962718 hasConcept C11882975 @default.
• W1980962718 hasConcept C120089663 @default.
• W1980962718 hasConcept C120504264 @default.
• W1980962718 hasConcept C124320809 @default.
• W1980962718 hasConcept C1491633281 @default.
• W1980962718 hasConcept C153911025 @default.
• W1980962718 hasConcept C16438837 @default.
• W1980962718 hasConcept C201750760 @default.
• W1980962718 hasConcept C2777863708 @default.
• W1980962718 hasConcept C2777918643 @default.
• W1980962718 hasConcept C2778437423 @default.
• W1980962718 hasConcept C2779705218 @default.
• W1980962718 hasConcept C28328180 @default.
• W1980962718 hasConcept C29537977 @default.
• W1980962718 hasConcept C54355233 @default.
• W1980962718 hasConcept C86803240 @default.
• W1980962718 hasConcept C93304396 @default.
• W1980962718 hasConcept C95444343 @default.
• W1980962718 hasConcept C9743823 @default.
• W1980962718 hasConceptScore W1980962718C109159458 @default.
• W1980962718 hasConceptScore W1980962718C11882975 @default.
• W1980962718 hasConceptScore W1980962718C120089663 @default.
• W1980962718 hasConceptScore W1980962718C120504264 @default.
• W1980962718 hasConceptScore W1980962718C124320809 @default.
• W1980962718 hasConceptScore W1980962718C1491633281 @default.
• W1980962718 hasConceptScore W1980962718C153911025 @default.
• W1980962718 hasConceptScore W1980962718C16438837 @default.
• W1980962718 hasConceptScore W1980962718C201750760 @default.
• W1980962718 hasConceptScore W1980962718C2777863708 @default.
• W1980962718 hasConceptScore W1980962718C2777918643 @default.
• W1980962718 hasConceptScore W1980962718C2778437423 @default.
• W1980962718 hasConceptScore W1980962718C2779705218 @default.
• W1980962718 hasConceptScore W1980962718C28328180 @default.
• W1980962718 hasConceptScore W1980962718C29537977 @default.
• W1980962718 hasConceptScore W1980962718C54355233 @default.
• W1980962718 hasConceptScore W1980962718C86803240 @default.
• W1980962718 hasConceptScore W1980962718C93304396 @default.
• W1980962718 hasConceptScore W1980962718C95444343 @default.
• W1980962718 hasConceptScore W1980962718C9743823 @default.
• W1980962718 hasIssue "4" @default.

• next