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• W1980978895 abstract "Although it is well known that vertebrate motoneurons are precisely connected to particular muscles, the mechanisms underlying this specificity have been controversial. Observations in various vertebrates have provided evidence for at least two views on the origins of neuromuscular specificity: it may arise (1) directly from the pathfinding abilities of motor growth cones that seek out the correct muscles to innervate; (2) from elimination of incorrect connections by later-acting mechanisms like cell death and competition; or (3) from a combination of these possibilities. Recent direct observations of growing motoneurons in live zebrafish embryos have demonstrated that each motor growth cone that pioneers a peripheral nerve follows a characteristic path and extends directly to the region of muscle appropriate for its adult function. Thus, correct neuromuscular connections in this system and perhaps in most systems arise, at least in part, by cell-specific pathfinding. Other mechanisms may be important later in development for establishing the number and precise distribution of muscle fibers innervated by each motoneuron." @default.
• W1980978895 created "2016-06-24" @default.
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• W1980978895 date "1988-01-01" @default.
• W1980978895 modified "2023-09-23" @default.
• W1980978895 title "Neuromuscular specificity: pathfinding by identified motor growth cones in a vertebrate embryo" @default.
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• W1980978895 doi "https://doi.org/10.1016/0166-2236(88)90044-6" @default.
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