Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980987243> ?p ?o ?g. }
- W1980987243 endingPage "24" @default.
- W1980987243 startingPage "17" @default.
- W1980987243 abstract "It has been shown previously that ATP is released into extracellular space from pre- and postsynaptic sources in peripheral synapses. The extracellular metabolism of ATP is likely to affect nucleotide- and nucleoside-mediated regulation of neurotransmission. The enzymes responsible for ATP breakdown are nucleotidases whose active site faces the extracellular space. ADPase and ADPase Ca2+-dependent activities were characterized in presynaptic plasma membrane preparation from the electric organ of Torpedo. Features described were in accordance with the presence of an ATP-diphosphohydrolase (apyrase EC 3.6.1.5) in this fraction. Active site studies using the affinity label 5′-fluorosulfonylbenzoyladenosine were performed on Torpedo apyrase. ADPase and ADPase Ca2+-dependent activities were inhibited with 5′-fluorosulfonylbenzoyladenosine. From this study it is concluded: (1) 5′-fluorosulfonylbenzoyladenosine binds specifically to the active site of apyrase. (2) Divalent cations accelerate the apyrase inactivation rate. (3) Divalent cations are not required for the binding of either the substrate or the inhibitor to the active site. (4) The apyrase active site is more specific for highly phosphorylated nucleotides. The results presented may be extrapolated to apyrases from other sources. The importance of this enzyme and its regulation are discussed." @default.
- W1980987243 created "2016-06-24" @default.
- W1980987243 creator A5028435751 @default.
- W1980987243 creator A5036119210 @default.
- W1980987243 creator A5075488745 @default.
- W1980987243 date "1996-06-01" @default.
- W1980987243 modified "2023-09-25" @default.
- W1980987243 title "Inhibition of ATP-diphosphohydrolase (apyrase) of Torpedo electric organ by 5′-p-fluorosulfonylbenzoyladenosine" @default.
- W1980987243 cites W1498488471 @default.
- W1980987243 cites W1501596101 @default.
- W1980987243 cites W1506387083 @default.
- W1980987243 cites W1550877969 @default.
- W1980987243 cites W1579399439 @default.
- W1980987243 cites W1594271424 @default.
- W1980987243 cites W1595014784 @default.
- W1980987243 cites W160914695 @default.
- W1980987243 cites W1766143736 @default.
- W1980987243 cites W1792542720 @default.
- W1980987243 cites W1963640512 @default.
- W1980987243 cites W1987682819 @default.
- W1980987243 cites W1989087586 @default.
- W1980987243 cites W1997990428 @default.
- W1980987243 cites W2001059387 @default.
- W1980987243 cites W2010073489 @default.
- W1980987243 cites W2011391497 @default.
- W1980987243 cites W2022703044 @default.
- W1980987243 cites W2023245703 @default.
- W1980987243 cites W2024462414 @default.
- W1980987243 cites W2028012325 @default.
- W1980987243 cites W2030341511 @default.
- W1980987243 cites W2040414052 @default.
- W1980987243 cites W2044262368 @default.
- W1980987243 cites W2047736282 @default.
- W1980987243 cites W2054974598 @default.
- W1980987243 cites W2055771038 @default.
- W1980987243 cites W2058856976 @default.
- W1980987243 cites W2062189193 @default.
- W1980987243 cites W2068941436 @default.
- W1980987243 cites W2071489012 @default.
- W1980987243 cites W2072569056 @default.
- W1980987243 cites W2092240707 @default.
- W1980987243 cites W2093804401 @default.
- W1980987243 cites W2103170292 @default.
- W1980987243 cites W2116990182 @default.
- W1980987243 cites W2125359741 @default.
- W1980987243 cites W2133505184 @default.
- W1980987243 cites W2180056482 @default.
- W1980987243 cites W2273970417 @default.
- W1980987243 cites W4293247451 @default.
- W1980987243 cites W61595453 @default.
- W1980987243 doi "https://doi.org/10.1016/0005-2736(96)00030-2" @default.
- W1980987243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8679655" @default.
- W1980987243 hasPublicationYear "1996" @default.
- W1980987243 type Work @default.
- W1980987243 sameAs 1980987243 @default.
- W1980987243 citedByCount "15" @default.
- W1980987243 countsByYear W19809872432014 @default.
- W1980987243 countsByYear W19809872432015 @default.
- W1980987243 crossrefType "journal-article" @default.
- W1980987243 hasAuthorship W1980987243A5028435751 @default.
- W1980987243 hasAuthorship W1980987243A5036119210 @default.
- W1980987243 hasAuthorship W1980987243A5075488745 @default.
- W1980987243 hasConcept C104317684 @default.
- W1980987243 hasConcept C107824862 @default.
- W1980987243 hasConcept C123419017 @default.
- W1980987243 hasConcept C12554922 @default.
- W1980987243 hasConcept C170493617 @default.
- W1980987243 hasConcept C178790620 @default.
- W1980987243 hasConcept C181199279 @default.
- W1980987243 hasConcept C185592680 @default.
- W1980987243 hasConcept C2776352584 @default.
- W1980987243 hasConcept C2776543447 @default.
- W1980987243 hasConcept C2779508331 @default.
- W1980987243 hasConcept C28406088 @default.
- W1980987243 hasConcept C41183919 @default.
- W1980987243 hasConcept C512185932 @default.
- W1980987243 hasConcept C55493867 @default.
- W1980987243 hasConcept C57306754 @default.
- W1980987243 hasConcept C74884574 @default.
- W1980987243 hasConcept C80161118 @default.
- W1980987243 hasConcept C86803240 @default.
- W1980987243 hasConceptScore W1980987243C104317684 @default.
- W1980987243 hasConceptScore W1980987243C107824862 @default.
- W1980987243 hasConceptScore W1980987243C123419017 @default.
- W1980987243 hasConceptScore W1980987243C12554922 @default.
- W1980987243 hasConceptScore W1980987243C170493617 @default.
- W1980987243 hasConceptScore W1980987243C178790620 @default.
- W1980987243 hasConceptScore W1980987243C181199279 @default.
- W1980987243 hasConceptScore W1980987243C185592680 @default.
- W1980987243 hasConceptScore W1980987243C2776352584 @default.
- W1980987243 hasConceptScore W1980987243C2776543447 @default.
- W1980987243 hasConceptScore W1980987243C2779508331 @default.
- W1980987243 hasConceptScore W1980987243C28406088 @default.
- W1980987243 hasConceptScore W1980987243C41183919 @default.
- W1980987243 hasConceptScore W1980987243C512185932 @default.
- W1980987243 hasConceptScore W1980987243C55493867 @default.
- W1980987243 hasConceptScore W1980987243C57306754 @default.
- W1980987243 hasConceptScore W1980987243C74884574 @default.