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- W1980991018 abstract "The proto-oncogene product c-Myc is a master regulator of cell proliferation by specific binding to the E-box motif in genomic DNA. It has been reported that c-Myc plays an important role in the proliferation and maintenance of pluripotency of embryonal stem (ES) cells and that the transcriptional activity of c-Myc is regulated by several posttranslational modifications including ubiquitination. In this study, we showed that TRIM6, one of the TRIM family ubiquitin ligases, is selectively expressed in ES cells and interacts with c-Myc followed by attenuation of transcriptional activity of c-Myc. Knockdown of TRIM6 in ES cells enhanced transcriptional activity of c-Myc and repressed expression of Nanog, resulting in promotion of the differentiation of ES cells. These findings indicate that TRIM6 regulates the transcriptional activity of c-Myc for maintaining pluripotency of ES cells, suggesting that TRIM6 functions as a novel regulator for c-Myc-mediated transcription in ES cells." @default.
- W1980991018 created "2016-06-24" @default.
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- W1980991018 date "2012-01-01" @default.
- W1980991018 modified "2023-10-16" @default.
- W1980991018 title "TRIM6 interacts with c-Myc and maintains pluripotency of mouse embryonal stem cells" @default.
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- W1980991018 doi "https://doi.org/10.1242/jcs.095273" @default.
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