Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980993810> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1980993810 endingPage "86" @default.
- W1980993810 startingPage "79" @default.
- W1980993810 abstract "Myocardial ischemia-reperfusion alters regional and systemic platelet function. The aim of our study was to elucidate the role of the Mac-1 receptor in changes of platelet function by using the leumedin, NPC-15669, an inhibitor of Mac-1 upregulation. In an open-chest swine model (n = 15), the treatment group (n = 6) received NPC-15669 (10mg/kg loading dose over 12 min at the rate of 5 ml/min at the onset of left-anterior descending coronary artery occlusion, followed by constant infusion at 6 mg kg–1 h–1 during 90 min of reperfusion). Regional platelet aggregation (response to 5 µM ADP) increased after 15 min occlusion (126% of baseline) and at 90 min of reperfusion (156% of baseline). This increase in platelet aggregability was inhibited by NPC-15669 (83% of baseline after 15 min occlusion and 98% of baseline at 90 min reperfusion, both p < 0.001 compared to control). Systemic platelet function was not affected by NPC-15669 after 15 min occlusion (102% of baseline vs. 96% of baseline for control, p = NS). At 90 min of reperfusion platelet function was increased in controls (131% of baseline) and not affected by NPC-15669 (126% of baseline, p = NS). Myocardial neutrophil accumulation did not differ between the control and treatment groups. Inhibition of Mac-1 upregulation by NPC-15669 attenuates the increased regional platelet aggregability resulting from myocardial ischemia-reperfusion, with a less marked effect on the systemic response. The data suggest that Mac-1 may modulate regional platelet responses induced by ischemia-reperfusion. The increased aggregability of platelets during ischemia and reperfusion and its attenuation by inhibition of Mac-1 may be relevant for future strategies to reduce coronary arterial occlusion by platelet thrombi." @default.
- W1980993810 created "2016-06-24" @default.
- W1980993810 creator A5000582387 @default.
- W1980993810 creator A5012918602 @default.
- W1980993810 creator A5049183658 @default.
- W1980993810 creator A5052219610 @default.
- W1980993810 creator A5079209201 @default.
- W1980993810 creator A5086533361 @default.
- W1980993810 creator A5089647146 @default.
- W1980993810 date "1996-01-01" @default.
- W1980993810 modified "2023-09-27" @default.
- W1980993810 title "Pretreatment with an Inhibitor of Mac-1 Alters Regional and Systemic Platelet Function during Ischemia-Reperfusion in Swine" @default.
- W1980993810 doi "https://doi.org/10.1159/000139418" @default.
- W1980993810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8902872" @default.
- W1980993810 hasPublicationYear "1996" @default.
- W1980993810 type Work @default.
- W1980993810 sameAs 1980993810 @default.
- W1980993810 citedByCount "6" @default.
- W1980993810 countsByYear W19809938102020 @default.
- W1980993810 crossrefType "journal-article" @default.
- W1980993810 hasAuthorship W1980993810A5000582387 @default.
- W1980993810 hasAuthorship W1980993810A5012918602 @default.
- W1980993810 hasAuthorship W1980993810A5049183658 @default.
- W1980993810 hasAuthorship W1980993810A5052219610 @default.
- W1980993810 hasAuthorship W1980993810A5079209201 @default.
- W1980993810 hasAuthorship W1980993810A5086533361 @default.
- W1980993810 hasAuthorship W1980993810A5089647146 @default.
- W1980993810 hasConcept C104317684 @default.
- W1980993810 hasConcept C126322002 @default.
- W1980993810 hasConcept C127561419 @default.
- W1980993810 hasConcept C164705383 @default.
- W1980993810 hasConcept C185592680 @default.
- W1980993810 hasConcept C2776268601 @default.
- W1980993810 hasConcept C3018697912 @default.
- W1980993810 hasConcept C42219234 @default.
- W1980993810 hasConcept C541997718 @default.
- W1980993810 hasConcept C55493867 @default.
- W1980993810 hasConcept C71924100 @default.
- W1980993810 hasConcept C89560881 @default.
- W1980993810 hasConceptScore W1980993810C104317684 @default.
- W1980993810 hasConceptScore W1980993810C126322002 @default.
- W1980993810 hasConceptScore W1980993810C127561419 @default.
- W1980993810 hasConceptScore W1980993810C164705383 @default.
- W1980993810 hasConceptScore W1980993810C185592680 @default.
- W1980993810 hasConceptScore W1980993810C2776268601 @default.
- W1980993810 hasConceptScore W1980993810C3018697912 @default.
- W1980993810 hasConceptScore W1980993810C42219234 @default.
- W1980993810 hasConceptScore W1980993810C541997718 @default.
- W1980993810 hasConceptScore W1980993810C55493867 @default.
- W1980993810 hasConceptScore W1980993810C71924100 @default.
- W1980993810 hasConceptScore W1980993810C89560881 @default.
- W1980993810 hasIssue "2" @default.
- W1980993810 hasLocation W19809938101 @default.
- W1980993810 hasLocation W19809938102 @default.
- W1980993810 hasOpenAccess W1980993810 @default.
- W1980993810 hasPrimaryLocation W19809938101 @default.
- W1980993810 hasRelatedWork W1980857487 @default.
- W1980993810 hasRelatedWork W2010986783 @default.
- W1980993810 hasRelatedWork W2026810294 @default.
- W1980993810 hasRelatedWork W2034628570 @default.
- W1980993810 hasRelatedWork W2076975908 @default.
- W1980993810 hasRelatedWork W2264309283 @default.
- W1980993810 hasRelatedWork W2388635932 @default.
- W1980993810 hasRelatedWork W2390249345 @default.
- W1980993810 hasRelatedWork W2400096344 @default.
- W1980993810 hasRelatedWork W2810236592 @default.
- W1980993810 hasVolume "53" @default.
- W1980993810 isParatext "false" @default.
- W1980993810 isRetracted "false" @default.
- W1980993810 magId "1980993810" @default.
- W1980993810 workType "article" @default.