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- W1980995792 abstract "We examined the impact of data source and exposure measurement error for ambient NO 2 on risk estimates derived from a case-crossover study of emergency room visits for asthma in Windsor, Canada between 2002 and 2009. Paired personal and fixed-site NO 2 data were available from an independent population (47 children and 48 adults) in Windsor between 2005 and 2006. We used linear regression to estimate the relationship and measurement error variance induced between fixed site and personal measurements of NO 2 , and through a series of simulations, evaluated the potential for a Bayesian model to adjust for this change in scale and measurement error. Finally, we re-analyzed data from the previous case-crossover study adjusting for the estimated change in slope and measurement error. Correlations between paired NO 2 measurements were weak ( R 2 ≤0.08) and slopes were far from unity (0.0029≤ β ≤0.30). Adjusting the previous case-crossover analysis suggested a much stronger association between personal NO 2 (per 1 ppb) (Odds Ratio (OR)=1.276, 95% Credible Interval (CrI): 1.034, 1.569) and emergency room visits for asthma among children relative to the fixed-site estimate (OR=1.024, 95% CrI 1.004–1.045). Our findings suggest that risk estimates based on fixed-site NO 2 concentrations may differ substantially from estimates based on personal exposures if the change in scale and/or measurement error is large. In practice, one must always keep the scale being used in mind when interpreting risk estimates and not assume that coefficients for ambient concentrations reflect risks at the personal level. • Fixed-site monitors provide imperfect measures of personal exposure to NO 2 . • A Bayesian model was used to adjust for this error in a case-control study of NO 2 and asthma. • Risk estimates based on fixed-site NO 2 differ substantially from those based on personal exposure." @default.
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- W1980995792 date "2015-02-01" @default.
- W1980995792 modified "2023-10-01" @default.
- W1980995792 title "Estimating risk of emergency room visits for asthma from personal versus fixed site measurements of NO2" @default.
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- W1980995792 doi "https://doi.org/10.1016/j.envres.2015.01.006" @default.
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