Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981000246> ?p ?o ?g. }
- W1981000246 endingPage "500" @default.
- W1981000246 startingPage "489" @default.
- W1981000246 abstract "Peptide and protein drugs are often formulated in the solid-state to provide stabilization during storage. However, reactions can occur in the solid-state, leading to degradation and inactivation of these agents. This review summarizes the major chemical reactions affecting proteins and peptides in the solid-state: deamidation, peptide bond cleavage, oxidation, the Maillard reaction, beta-elimination, and dimerization/aggregation. Physical and chemical factors influencing these reactions are also discussed. These include temperature, moisture content, excipients, and the physical state of the formulation (amorphous vs crystalline). The review is intended to serve as an aid for those involved in formulation, and to stimulate further research on the determinants of peptide and protein reactivity in the solid-state." @default.
- W1981000246 created "2016-06-24" @default.
- W1981000246 creator A5004862104 @default.
- W1981000246 creator A5011722630 @default.
- W1981000246 date "1999-05-01" @default.
- W1981000246 modified "2023-10-14" @default.
- W1981000246 title "Solid‐state chemical stability of proteins and peptides" @default.
- W1981000246 cites W1276324155 @default.
- W1981000246 cites W146313412 @default.
- W1981000246 cites W1497812247 @default.
- W1981000246 cites W1500726846 @default.
- W1981000246 cites W1511036913 @default.
- W1981000246 cites W1511344763 @default.
- W1981000246 cites W1525552580 @default.
- W1981000246 cites W1527234172 @default.
- W1981000246 cites W1534792972 @default.
- W1981000246 cites W1539001309 @default.
- W1981000246 cites W1541736117 @default.
- W1981000246 cites W1547597445 @default.
- W1981000246 cites W1582009577 @default.
- W1981000246 cites W1597771956 @default.
- W1981000246 cites W1600942466 @default.
- W1981000246 cites W184211056 @default.
- W1981000246 cites W1944789189 @default.
- W1981000246 cites W195560163 @default.
- W1981000246 cites W1986673901 @default.
- W1981000246 cites W1987690443 @default.
- W1981000246 cites W1994372191 @default.
- W1981000246 cites W2003253638 @default.
- W1981000246 cites W2004927126 @default.
- W1981000246 cites W2006734937 @default.
- W1981000246 cites W2029153754 @default.
- W1981000246 cites W2032888813 @default.
- W1981000246 cites W2041422272 @default.
- W1981000246 cites W2043769598 @default.
- W1981000246 cites W2045140664 @default.
- W1981000246 cites W2061153822 @default.
- W1981000246 cites W2063385184 @default.
- W1981000246 cites W2072441996 @default.
- W1981000246 cites W2073502936 @default.
- W1981000246 cites W2074061676 @default.
- W1981000246 cites W2082203116 @default.
- W1981000246 cites W2091541780 @default.
- W1981000246 cites W2092774999 @default.
- W1981000246 cites W2095184733 @default.
- W1981000246 cites W2106411129 @default.
- W1981000246 cites W2106498165 @default.
- W1981000246 cites W2114000888 @default.
- W1981000246 cites W2123614220 @default.
- W1981000246 cites W2142483595 @default.
- W1981000246 cites W2146128579 @default.
- W1981000246 cites W2182427056 @default.
- W1981000246 cites W222437802 @default.
- W1981000246 cites W2323111824 @default.
- W1981000246 cites W286847924 @default.
- W1981000246 cites W29913768 @default.
- W1981000246 cites W342034725 @default.
- W1981000246 cites W42925865 @default.
- W1981000246 cites W57282146 @default.
- W1981000246 cites W58904424 @default.
- W1981000246 cites W66053814 @default.
- W1981000246 cites W8879306 @default.
- W1981000246 doi "https://doi.org/10.1021/js980374e" @default.
- W1981000246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10229638" @default.
- W1981000246 hasPublicationYear "1999" @default.
- W1981000246 type Work @default.
- W1981000246 sameAs 1981000246 @default.
- W1981000246 citedByCount "239" @default.
- W1981000246 countsByYear W19810002462012 @default.
- W1981000246 countsByYear W19810002462013 @default.
- W1981000246 countsByYear W19810002462014 @default.
- W1981000246 countsByYear W19810002462015 @default.
- W1981000246 countsByYear W19810002462016 @default.
- W1981000246 countsByYear W19810002462017 @default.
- W1981000246 countsByYear W19810002462018 @default.
- W1981000246 countsByYear W19810002462019 @default.
- W1981000246 countsByYear W19810002462020 @default.
- W1981000246 countsByYear W19810002462021 @default.
- W1981000246 countsByYear W19810002462022 @default.
- W1981000246 countsByYear W19810002462023 @default.
- W1981000246 crossrefType "journal-article" @default.
- W1981000246 hasAuthorship W1981000246A5004862104 @default.
- W1981000246 hasAuthorship W1981000246A5011722630 @default.
- W1981000246 hasConcept C107814960 @default.
- W1981000246 hasConcept C142724271 @default.
- W1981000246 hasConcept C147789679 @default.
- W1981000246 hasConcept C159985019 @default.
- W1981000246 hasConcept C175156509 @default.
- W1981000246 hasConcept C177801218 @default.
- W1981000246 hasConcept C178790620 @default.
- W1981000246 hasConcept C181199279 @default.
- W1981000246 hasConcept C185592680 @default.
- W1981000246 hasConcept C186399102 @default.
- W1981000246 hasConcept C192562407 @default.
- W1981000246 hasConcept C204787440 @default.
- W1981000246 hasConcept C21951064 @default.
- W1981000246 hasConcept C2776910235 @default.
- W1981000246 hasConcept C2779281246 @default.