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• W1981004020 abstract "Lysophospholipid (LPL) has long been recognized as a membrane phospholipid metabolite. Recently, however, the LPL has emerged as a candidate for diagnostic and pharmacological interest. LPLs include lysophosphatidic acid (LPA), alkyl glycerol phosphate (AGP), cyclic phosphatidic acid (cPA), and sphingosine-1-phosphate (S1P). These biologically active lipid mediators serve to promote a variety of responses that include cell proliferation, migration, and survival. These LPL-related responses are mediated by cell surface G-protein-coupled receptors and also intracellular receptor peroxisome proliferator-activated receptor gamma (PPAR γ ). In this paper, we focus mainly on the most recent findings regarding the biological function of nuclear receptor-mediated lysophospholipid signaling in mammalian systems, specifically as they relate to health and diseases. Also, we will briefly review the biology of PPAR γ and then provide an update of lysophospholipids PPAR γ ligands that are under investigation as a therapeutic compound and which are targets of PPAR γ relevant to diseases." @default.
• W1981004020 created "2016-06-24" @default.
• W1981004020 creator A5046108185 @default.
• W1981004020 date "2013-01-01" @default.
• W1981004020 modified "2023-10-15" @default.
• W1981004020 title "PPAR<b><i>γ</i></b>Networks in Cell Signaling: Update and Impact of Cyclic Phosphatidic Acid" @default.
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• W1981004020 doi "https://doi.org/10.1155/2013/246597" @default.
• W1981004020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3582055" @default.
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