Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981008156> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1981008156 abstract "Abstract The effect of a prodrug-based colonie delivery system on carrageenan-induced inflammatory bowel disease (IBD) in guinea-pigs was investigated. Guinea-pigs were administered 4 wt.% of degraded carrageenan in the drinking water for 2 weeks to induce experimental IBD. The prodrug, dexamethasone-β- d -glucoside, was then administered at one of two dose levels (1.3 or 0.65 μmol/kg) once daily by gastric intubation for 5 days; dexamethasone (1.3 μmol/kg) was also administered in the same manner. The higher dose of dexamethasone-β- d -glucoside led to reduced gross pathologic effects (fluid cecal contents, redness, edema, ulcerations), and a significantly lower histopathologic score relative to dexamethasone, which was ineffective at controlling the inflammatory response relative to control animals. The lower dose of prodrug was somewhat more effective than dexamethasone or no drug treatment in controlling gross pathologic effects of the large intestine, but was ineffective when evaluated histologically. The implications of these findings are discussed." @default.
- W1981008156 created "2016-06-24" @default.
- W1981008156 creator A5018390857 @default.
- W1981008156 creator A5065082001 @default.
- W1981008156 creator A5081233453 @default.
- W1981008156 date "1991-02-01" @default.
- W1981008156 modified "2023-09-26" @default.
- W1981008156 title "Colon-specific drug delivery from a glucoside prodrug in the guinea-pig. Efficacy study" @default.
- W1981008156 cites W1582088281 @default.
- W1981008156 cites W1974104914 @default.
- W1981008156 cites W1980715469 @default.
- W1981008156 cites W1983341954 @default.
- W1981008156 cites W1987349056 @default.
- W1981008156 cites W2009032179 @default.
- W1981008156 cites W2019657479 @default.
- W1981008156 cites W2048943315 @default.
- W1981008156 cites W2054685169 @default.
- W1981008156 cites W2088738262 @default.
- W1981008156 cites W2093300894 @default.
- W1981008156 cites W2100970832 @default.
- W1981008156 cites W2107698385 @default.
- W1981008156 cites W2126444453 @default.
- W1981008156 cites W2133823540 @default.
- W1981008156 cites W2135287750 @default.
- W1981008156 cites W2175127203 @default.
- W1981008156 cites W286706559 @default.
- W1981008156 doi "https://doi.org/10.1016/0168-3659(91)90102-j" @default.
- W1981008156 hasPublicationYear "1991" @default.
- W1981008156 type Work @default.
- W1981008156 sameAs 1981008156 @default.
- W1981008156 citedByCount "22" @default.
- W1981008156 countsByYear W19810081562014 @default.
- W1981008156 countsByYear W19810081562015 @default.
- W1981008156 countsByYear W19810081562020 @default.
- W1981008156 crossrefType "journal-article" @default.
- W1981008156 hasAuthorship W1981008156A5018390857 @default.
- W1981008156 hasAuthorship W1981008156A5065082001 @default.
- W1981008156 hasAuthorship W1981008156A5081233453 @default.
- W1981008156 hasConcept C108215921 @default.
- W1981008156 hasConcept C126322002 @default.
- W1981008156 hasConcept C2778815084 @default.
- W1981008156 hasConcept C2780035454 @default.
- W1981008156 hasConcept C2780401358 @default.
- W1981008156 hasConcept C2780886150 @default.
- W1981008156 hasConcept C2781227287 @default.
- W1981008156 hasConcept C71924100 @default.
- W1981008156 hasConcept C98274493 @default.
- W1981008156 hasConceptScore W1981008156C108215921 @default.
- W1981008156 hasConceptScore W1981008156C126322002 @default.
- W1981008156 hasConceptScore W1981008156C2778815084 @default.
- W1981008156 hasConceptScore W1981008156C2780035454 @default.
- W1981008156 hasConceptScore W1981008156C2780401358 @default.
- W1981008156 hasConceptScore W1981008156C2780886150 @default.
- W1981008156 hasConceptScore W1981008156C2781227287 @default.
- W1981008156 hasConceptScore W1981008156C71924100 @default.
- W1981008156 hasConceptScore W1981008156C98274493 @default.
- W1981008156 hasLocation W19810081561 @default.
- W1981008156 hasOpenAccess W1981008156 @default.
- W1981008156 hasPrimaryLocation W19810081561 @default.
- W1981008156 hasRelatedWork W126201954 @default.
- W1981008156 hasRelatedWork W1652799882 @default.
- W1981008156 hasRelatedWork W1973960461 @default.
- W1981008156 hasRelatedWork W1983341954 @default.
- W1981008156 hasRelatedWork W1995977958 @default.
- W1981008156 hasRelatedWork W2016928576 @default.
- W1981008156 hasRelatedWork W2019564380 @default.
- W1981008156 hasRelatedWork W2027867890 @default.
- W1981008156 hasRelatedWork W2043606915 @default.
- W1981008156 hasRelatedWork W2058495944 @default.
- W1981008156 hasRelatedWork W2063680989 @default.
- W1981008156 hasRelatedWork W2066687954 @default.
- W1981008156 hasRelatedWork W2089407496 @default.
- W1981008156 hasRelatedWork W2093300894 @default.
- W1981008156 hasRelatedWork W2111768445 @default.
- W1981008156 hasRelatedWork W2163426424 @default.
- W1981008156 hasRelatedWork W2278246503 @default.
- W1981008156 hasRelatedWork W2416734676 @default.
- W1981008156 hasRelatedWork W265831160 @default.
- W1981008156 hasRelatedWork W289880891 @default.
- W1981008156 isParatext "false" @default.
- W1981008156 isRetracted "false" @default.
- W1981008156 magId "1981008156" @default.
- W1981008156 workType "article" @default.