FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981013674> ?p ?o ?g. }

• W1981013674 endingPage "422" @default.
• W1981013674 startingPage "415" @default.
• W1981013674 abstract "The results of DNA binding properties for four selected N-substituted 9,10-bis(aminomethyl)anthracenes are presented. DNA binding affinities were studied using UV–vis and fluorescence spectrophotometric titrations, CD spectroscopy, denaturation transition temperature (Tm) measurements and AM1 quantum chemical calculations. The results obtained indicate that the anthracene products intercalate into the stacked base pairs of DNA with binding constants, K, in the range 1.3–10.9 × 105 M−1 and the binding site size in DNA-base pairs, n, extending over the range 2.4–4.6. Tm values increased in the presence of the anthryl probes, thereby reflecting an increased stability of the calf-thymus (CT) DNA double helix and rendering agreement with the spectrometric titration results. The synthesized compounds were tested against L1210 and HeLa tumor cell lines wherein the HeLa cells appeared to be more sensitive than the L1210 cells. 9,10-Bis{[2-(piperazin-1-yl)ethyl]aminomethyl}anthracene exhibited the highest activity of the tested compounds. Our findings were compared with those of a control drug bisantrene." @default.
• W1981013674 created "2016-06-24" @default.
• W1981013674 creator A5006189027 @default.
• W1981013674 creator A5016481285 @default.
• W1981013674 creator A5029139522 @default.
• W1981013674 creator A5029163210 @default.
• W1981013674 creator A5031419076 @default.
• W1981013674 creator A5043596411 @default.
• W1981013674 creator A5050920826 @default.
• W1981013674 creator A5074839041 @default.
• W1981013674 creator A5091477059 @default.
• W1981013674 date "2007-10-01" @default.
• W1981013674 modified "2023-09-26" @default.
• W1981013674 title "DNA binding properties and evaluation of cytotoxic activity of 9,10-bis-N-substituted (aminomethyl)anthracenes" @default.
• W1981013674 cites W1973241584 @default.
• W1981013674 cites W1979759975 @default.
• W1981013674 cites W1980235765 @default.
• W1981013674 cites W1985450531 @default.
• W1981013674 cites W1989651677 @default.
• W1981013674 cites W1993206757 @default.
• W1981013674 cites W1998034955 @default.
• W1981013674 cites W2013548632 @default.
• W1981013674 cites W2020109700 @default.
• W1981013674 cites W2022950330 @default.
• W1981013674 cites W2034325171 @default.
• W1981013674 cites W2056783442 @default.
• W1981013674 cites W2057403031 @default.
• W1981013674 cites W2062080271 @default.
• W1981013674 cites W2068509261 @default.
• W1981013674 cites W2084016670 @default.
• W1981013674 cites W2095540277 @default.
• W1981013674 cites W2113357785 @default.
• W1981013674 cites W2173807279 @default.
• W1981013674 cites W2951268479 @default.
• W1981013674 doi "https://doi.org/10.1016/j.ijbiomac.2007.05.013" @default.
• W1981013674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17659335" @default.
• W1981013674 hasPublicationYear "2007" @default.
• W1981013674 type Work @default.
• W1981013674 sameAs 1981013674 @default.
• W1981013674 citedByCount "43" @default.
• W1981013674 countsByYear W19810136742012 @default.
• W1981013674 countsByYear W19810136742013 @default.
• W1981013674 countsByYear W19810136742014 @default.
• W1981013674 countsByYear W19810136742015 @default.
• W1981013674 countsByYear W19810136742016 @default.
• W1981013674 countsByYear W19810136742017 @default.
• W1981013674 countsByYear W19810136742018 @default.
• W1981013674 countsByYear W19810136742019 @default.
• W1981013674 countsByYear W19810136742020 @default.
• W1981013674 countsByYear W19810136742021 @default.
• W1981013674 crossrefType "journal-article" @default.
• W1981013674 hasAuthorship W1981013674A5006189027 @default.
• W1981013674 hasAuthorship W1981013674A5016481285 @default.
• W1981013674 hasAuthorship W1981013674A5029139522 @default.
• W1981013674 hasAuthorship W1981013674A5029163210 @default.
• W1981013674 hasAuthorship W1981013674A5031419076 @default.
• W1981013674 hasAuthorship W1981013674A5043596411 @default.
• W1981013674 hasAuthorship W1981013674A5050920826 @default.
• W1981013674 hasAuthorship W1981013674A5074839041 @default.
• W1981013674 hasAuthorship W1981013674A5091477059 @default.
• W1981013674 hasConcept C107824862 @default.
• W1981013674 hasConcept C121332964 @default.
• W1981013674 hasConcept C133571119 @default.
• W1981013674 hasConcept C137824038 @default.
• W1981013674 hasConcept C147789679 @default.
• W1981013674 hasConcept C178790620 @default.
• W1981013674 hasConcept C184866935 @default.
• W1981013674 hasConcept C185581394 @default.
• W1981013674 hasConcept C185592680 @default.
• W1981013674 hasConcept C202751555 @default.
• W1981013674 hasConcept C2777366897 @default.
• W1981013674 hasConcept C2779563022 @default.
• W1981013674 hasConcept C32786932 @default.
• W1981013674 hasConcept C552990157 @default.
• W1981013674 hasConcept C55493867 @default.
• W1981013674 hasConcept C62520636 @default.
• W1981013674 hasConcept C71240020 @default.
• W1981013674 hasConcept C75473681 @default.
• W1981013674 hasConcept C8010536 @default.
• W1981013674 hasConcept C91881484 @default.
• W1981013674 hasConceptScore W1981013674C107824862 @default.
• W1981013674 hasConceptScore W1981013674C121332964 @default.
• W1981013674 hasConceptScore W1981013674C133571119 @default.
• W1981013674 hasConceptScore W1981013674C137824038 @default.
• W1981013674 hasConceptScore W1981013674C147789679 @default.
• W1981013674 hasConceptScore W1981013674C178790620 @default.
• W1981013674 hasConceptScore W1981013674C184866935 @default.
• W1981013674 hasConceptScore W1981013674C185581394 @default.
• W1981013674 hasConceptScore W1981013674C185592680 @default.
• W1981013674 hasConceptScore W1981013674C202751555 @default.
• W1981013674 hasConceptScore W1981013674C2777366897 @default.
• W1981013674 hasConceptScore W1981013674C2779563022 @default.
• W1981013674 hasConceptScore W1981013674C32786932 @default.
• W1981013674 hasConceptScore W1981013674C552990157 @default.
• W1981013674 hasConceptScore W1981013674C55493867 @default.
• W1981013674 hasConceptScore W1981013674C62520636 @default.
• W1981013674 hasConceptScore W1981013674C71240020 @default.
• W1981013674 hasConceptScore W1981013674C75473681 @default.

• next