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- W1981014384 abstract "Hunchback (Hb) is a bifunctional transcription factor that activates and represses distinct enhancers. Here, we investigate the hypothesis that Hb can activate and repress the same enhancer. Computational models predicted that Hb bifunctionally regulates the even-skipped (eve) stripe 3+7 enhancer (eve3+7) in Drosophila blastoderm embryos. We measured and modeled eve expression at cellular resolution under multiple genetic perturbations and found that the eve3+7 enhancer could not explain endogenous eve stripe 7 behavior. Instead, we found that eve stripe 7 is controlled by two enhancers: the canonical eve3+7 and a sequence encompassing the minimal eve stripe 2 enhancer (eve2+7). Hb bifunctionally regulates eve stripe 7, but it executes these two activities on different pieces of regulatory DNA--it activates the eve2+7 enhancer and represses the eve3+7 enhancer. These two shadow enhancers use different regulatory logic to create the same pattern." @default.
- W1981014384 created "2016-06-24" @default.
- W1981014384 creator A5015328271 @default.
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- W1981014384 date "2015-01-06" @default.
- W1981014384 modified "2023-10-16" @default.
- W1981014384 title "Shadow enhancers enable Hunchback bifunctionality in the <i>Drosophila</i> embryo" @default.
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- W1981014384 doi "https://doi.org/10.1073/pnas.1413877112" @default.
- W1981014384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4311800" @default.
- W1981014384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25564665" @default.
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