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• W1981016146 abstract "Journal of Molecular and Cellular Cardiology (1995) 27. 501-511. We have studied the effects of pressure and volume overload as well as of norepinephrine (NE) alone and in combination on the expression of the proto-oncogenes c-fos and c-myc in isolated perfused working rat hearts. Using specific cDNA clones, the mRNAs of c-fos and c-myc were measured by Northern blots and quantified with densitometry. Total RNA was isolated from hearts after stimulation with NE (3 × 10-8 m), after increasing left atrial filling pressure (preload) from 8 to 16 cmH2, and after elevation of afterload from 80 to 100 cmH2 for for 15, 30, 60, 90, and 120 min. NE increased the expression of c-fos and c-myc after 30 and 60 min, respectively. This enhancement occurred at about the same time as that induced by elevation of pre-and afterload, but was more pronounced. Combination of NE with pre- and afterload elevation induced the c-fos mRNA signal to appear earlier and to persist for a longer period of time. Similar results were obtained in regard to the c-myc mRNA, however, the signal was more pronounced in intensity. Simultaneous pre- and afterload increase also led to an earlier expression of the proto-oncogenes and to a longer duration of the signals. These results indicate that the combination of two hypertrophy-inducing stimuli, which may cause a higher degree of cardiac hypertrophy in vivo, induce an earlier, more pronounced and longer-lasting expression of the proto-oncogenes c-fos and c-myc. Journal of Molecular and Cellular Cardiology (1995) 27. 501-511. We have studied the effects of pressure and volume overload as well as of norepinephrine (NE) alone and in combination on the expression of the proto-oncogenes c-fos and c-myc in isolated perfused working rat hearts. Using specific cDNA clones, the mRNAs of c-fos and c-myc were measured by Northern blots and quantified with densitometry. Total RNA was isolated from hearts after stimulation with NE (3 × 10-8 m), after increasing left atrial filling pressure (preload) from 8 to 16 cmH2, and after elevation of afterload from 80 to 100 cmH2 for for 15, 30, 60, 90, and 120 min. NE increased the expression of c-fos and c-myc after 30 and 60 min, respectively. This enhancement occurred at about the same time as that induced by elevation of pre-and afterload, but was more pronounced. Combination of NE with pre- and afterload elevation induced the c-fos mRNA signal to appear earlier and to persist for a longer period of time. Similar results were obtained in regard to the c-myc mRNA, however, the signal was more pronounced in intensity. Simultaneous pre- and afterload increase also led to an earlier expression of the proto-oncogenes and to a longer duration of the signals. These results indicate that the combination of two hypertrophy-inducing stimuli, which may cause a higher degree of cardiac hypertrophy in vivo, induce an earlier, more pronounced and longer-lasting expression of the proto-oncogenes c-fos and c-myc." @default.
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• W1981016146 date "1995-01-01" @default.
• W1981016146 modified "2023-09-25" @default.
• W1981016146 title "Proto-oncogene expression in the isolated working rat heart: combination of pressure and volume overload with norepinephrine" @default.
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• W1981016146 doi "https://doi.org/10.1016/s0022-2828(08)80045-4" @default.
• W1981016146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7760370" @default.
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