FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981016365> ?p ?o ?g. }

• W1981016365 endingPage "28864" @default.
• W1981016365 startingPage "28856" @default.
• W1981016365 abstract "Ca²⁺ homeostasis is a vital cellular control mechanism in which Ca²⁺ release from intracellular stores plays a central role. Ryanodine receptor (RyR)-mediated Ca²⁺ release is a key modulator of Ca²⁺ homeostasis, and the defective regulation of RyR is pathogenic. However, the molecular events underlying RyR-mediated pathology remain undefined. Cells stably expressing recombinant human RyR2 (Chinese hamster ovary cells, CHO^hRyR2) had similar resting cytoplasmic Ca²⁺ levels ([Ca²⁺]_c) to wild-type CHO cells (CHO^WT) but exhibited increased cytoplasmic Ca²⁺ flux associated with decreased cell viability and proliferation. Intracellular Ca²⁺ flux increased with human RyR2 (hRyR2) expression levels and determined the extent of phenotypic modulation. Co-expression of FKBP12.6, but not FKBP12, or incubation of cells with ryanodine suppressed intracellular Ca²⁺ flux and restored normal cell viability and proliferation. Restoration of normal phenotype was independent of the status of resting [Ca²⁺]_c or ER Ca²⁺ load. Heparin inhibition of endogenous inositol trisphosphate receptors (IP₃R) had little effect on intracellular Ca²⁺ handling or viability. However, purinergic stimulation of endogenous IP₃R resulted in apoptotic cell death mediated by hRyR2 suggesting functional interaction occurred between IP₃R and hRyR2 Ca²⁺ release channels. These data demonstrate that defective regulation of RyR causes altered cellular phenotype via profound perturbations in intracellular Ca²⁺ signaling and highlight a key modulatory role of FKBP12.6 in hRyR2 Ca²⁺ channel function." @default.
• W1981016365 created "2016-06-24" @default.
• W1981016365 creator A5017275427 @default.
• W1981016365 creator A5018491605 @default.
• W1981016365 creator A5058027348 @default.
• W1981016365 creator A5071636673 @default.
• W1981016365 date "2003-08-01" @default.
• W1981016365 modified "2023-09-28" @default.
• W1981016365 title "Dysregulated Ryanodine Receptors Mediate Cellular Toxicity" @default.
• W1981016365 cites W1522775437 @default.
• W1981016365 cites W1526274619 @default.
• W1981016365 cites W1599277155 @default.
• W1981016365 cites W1792891338 @default.
• W1981016365 cites W1936688462 @default.
• W1981016365 cites W1958742527 @default.
• W1981016365 cites W1977150932 @default.
• W1981016365 cites W1981753053 @default.
• W1981016365 cites W1984843607 @default.
• W1981016365 cites W1988859333 @default.
• W1981016365 cites W1990285880 @default.
• W1981016365 cites W1991889754 @default.
• W1981016365 cites W1994284629 @default.
• W1981016365 cites W1997403679 @default.
• W1981016365 cites W2000451431 @default.
• W1981016365 cites W2002117041 @default.
• W1981016365 cites W2002487087 @default.
• W1981016365 cites W2007320632 @default.
• W1981016365 cites W2026768427 @default.
• W1981016365 cites W2034998738 @default.
• W1981016365 cites W2035578875 @default.
• W1981016365 cites W2036810289 @default.
• W1981016365 cites W2045326768 @default.
• W1981016365 cites W2046353863 @default.
• W1981016365 cites W2050780119 @default.
• W1981016365 cites W2051450681 @default.
• W1981016365 cites W2065693120 @default.
• W1981016365 cites W2070264051 @default.
• W1981016365 cites W2071001965 @default.
• W1981016365 cites W2084314209 @default.
• W1981016365 cites W2084488755 @default.
• W1981016365 cites W2092502706 @default.
• W1981016365 cites W2102909249 @default.
• W1981016365 cites W2102959417 @default.
• W1981016365 cites W2103879047 @default.
• W1981016365 cites W2117581921 @default.
• W1981016365 cites W2119830751 @default.
• W1981016365 cites W2124346025 @default.
• W1981016365 cites W2129220177 @default.
• W1981016365 cites W2131133264 @default.
• W1981016365 cites W2131549396 @default.
• W1981016365 cites W2133466768 @default.
• W1981016365 cites W2140313980 @default.
• W1981016365 cites W2148049759 @default.
• W1981016365 cites W2150396353 @default.
• W1981016365 cites W2154184264 @default.
• W1981016365 cites W2163529058 @default.
• W1981016365 cites W2165161047 @default.
• W1981016365 cites W4249759827 @default.
• W1981016365 cites W48742315 @default.
• W1981016365 doi "https://doi.org/10.1074/jbc.m212440200" @default.
• W1981016365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12754204" @default.
• W1981016365 hasPublicationYear "2003" @default.
• W1981016365 type Work @default.
• W1981016365 sameAs 1981016365 @default.
• W1981016365 citedByCount "29" @default.
• W1981016365 countsByYear W19810163652012 @default.
• W1981016365 countsByYear W19810163652013 @default.
• W1981016365 countsByYear W19810163652014 @default.
• W1981016365 countsByYear W19810163652015 @default.
• W1981016365 countsByYear W19810163652016 @default.
• W1981016365 countsByYear W19810163652017 @default.
• W1981016365 crossrefType "journal-article" @default.
• W1981016365 hasAuthorship W1981016365A5017275427 @default.
• W1981016365 hasAuthorship W1981016365A5018491605 @default.
• W1981016365 hasAuthorship W1981016365A5058027348 @default.
• W1981016365 hasAuthorship W1981016365A5071636673 @default.
• W1981016365 hasBestOaLocation W19810163651 @default.
• W1981016365 hasConcept C113217602 @default.
• W1981016365 hasConcept C153911025 @default.
• W1981016365 hasConcept C170493617 @default.
• W1981016365 hasConcept C175656101 @default.
• W1981016365 hasConcept C185592680 @default.
• W1981016365 hasConcept C2777427919 @default.
• W1981016365 hasConcept C55493867 @default.
• W1981016365 hasConcept C79879829 @default.
• W1981016365 hasConcept C86803240 @default.
• W1981016365 hasConceptScore W1981016365C113217602 @default.
• W1981016365 hasConceptScore W1981016365C153911025 @default.
• W1981016365 hasConceptScore W1981016365C170493617 @default.
• W1981016365 hasConceptScore W1981016365C175656101 @default.
• W1981016365 hasConceptScore W1981016365C185592680 @default.
• W1981016365 hasConceptScore W1981016365C2777427919 @default.
• W1981016365 hasConceptScore W1981016365C55493867 @default.
• W1981016365 hasConceptScore W1981016365C79879829 @default.
• W1981016365 hasConceptScore W1981016365C86803240 @default.
• W1981016365 hasIssue "31" @default.
• W1981016365 hasLocation W19810163651 @default.
• W1981016365 hasOpenAccess W1981016365 @default.

• next