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- W1981017846 abstract "We have purified the Xenopus histone acetyltransferase Hat1 holoenzyme from oocytes. The holoenzyme contains the catalytic subunit Hat1, the retinoblastoma associated protein RbAp48, and members of the phosphoserine binding family of 14-3-3 proteins. We have determined that the Hat1 holoenzyme specifically acetylates free histone H4 but not nucleosomal histones. RbAp48 is a phosphoprotein that contains a consensus recognition motif for the 14-3-3 proteins. The 14-3-3 proteins provide a regulatory function for the activity of many phosphoproteins. We find that the hugely abundant Hat1 holoenzyme is present in 10 000-fold excess over somatic cell levels. The holoenzyme is localized in the oocyte nucleus where acetylated histones are stored. The oocyte form of the Xenopus Hat1 holoenzyme may represent a specialized storage form of histone acetyltransferase. Following oocyte maturation and subsequent embryogenesis, the Hat1 enzyme is redistributed to the cytoplasm, where new histones are synthesized." @default.
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- W1981017846 date "1999-09-14" @default.
- W1981017846 modified "2023-10-13" @default.
- W1981017846 title "Purification and Properties of the <i>Xenopus</i> Hat1 Acetyltransferase: Association with the 14-3-3 Proteins in the Oocyte Nucleus" @default.
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- W1981017846 doi "https://doi.org/10.1021/bi9912490" @default.
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