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• W1981018826 abstract "The N4-macrocyclic ligand 2,10-dioxo-1,4,8,11-tetraazabicyclo[11.4.0]1,12-heptadeca-1(12),14,16-triene H2L has been synthesized by the [1 + 1] condensation reaction between N,N′-bis(chloroacetyl)-1,2-phenylenediamine and 1,3-propylenediamine. The coordination chemistry of this ligand has been investigated with the metal ions Cu(II), Ni(II), Zn(II), and Ga(III) (complexes 1, 2, 3 and 4, respectively). H2L and its metal complexes have been fully characterized by the use of NMR, UV/vis, electron paramagnetic resonance, and elemental analysis where appropriate. The four metal complexes 1−4 have been structurally characterized by X-ray crystallography which confirmed that in all cases the amide nitrogen atoms are deprotonated and coordinated to the metal center. Complexes 3 and 4 are five-coordinate with a water molecule and chloride ion occupying the apical site, respectively. Cyclic voltammetric measurements on complex 1 show that this complex is oxidized reversibly with a half-wave potential, E1/2 = 0.47 V, and reduced irreversibly at EP = −1.84 V. Density functional theory calculations reproduce the geometries of the four complexes. The one-electron reduction and oxidation potentials for 1 were calculated by using two solvent models, DMF and H2O. The calculations indicated that the one electron oxidation of 1 may involve removal of an electron from the ligand as opposed to the metal center, producing a diradical. The diamide macrocyle is of interest for the development of new positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging agents, and a radiolabeled complex has been synthesized with the positron emitting isotope 64Cu. In vivo biodistribution studies for the 64Cu labeled complex, 64Cu-1, in male Lewis rats, showed that the activity is cleared rapidly from the blood within 1−2 h post-administration." @default.
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• W1981018826 date "2009-07-09" @default.
• W1981018826 modified "2023-10-16" @default.
• W1981018826 title "Macrocyclic Diamide Ligand Systems: Potential Chelators for ⁶⁴Cu- and ⁶⁸Ga-Based Positron Emission Tomography Imaging Agents" @default.
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• W1981018826 doi "https://doi.org/10.1021/ic900307f" @default.
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