Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981019503> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1981019503 endingPage "171" @default.
- W1981019503 startingPage "168" @default.
- W1981019503 abstract "The rejection of organs transplanted between phylogenetically disparate species is thought to be initiated by the binding of naturally occurring antibodies of the recipient to the endothelium lining the blood vessels of the donor organ. We recently showed that among the xenoreactive natural antibodies in human serum that react with porcine endothelial cells and endothelial cell--derived glycoproteins are polyreactive antibodies. To test whether polyreactive natural antibodies are present in rejected xenografts we developed a series of hybridoma-derived antibodies specific for the polyreactive human monoclonal antibody 103, which we have shown to bind efficiently to porcine endothelial cells. Using these antiidiotypic reagents we detected antibodies bearing the 103 idiotype in a panel of human sera and on the surface of lymphocytes in the spleen of humans, rhesus monkeys, and baboons. The antiidiotypic reagents reacted in a pattern similar to the distribution of IgM, with immunoglobulin deposits in tissues obtained from pig-to-rhesus monkey and pig-to-baboon xenografts. Analysis of immunoglobulin eluted from these sites showed that they antibodies display the antigen-binding features of natural antibodies. Our findings are consistent with the hypothesis that idiotypes of polyreactive natural antibodies are broadly crossreactive. They also suggest that the polyreactive and xenoreactive IgM, which have been detected based on in vitro assays, may be deposited in a xenogeneic organ graft." @default.
- W1981019503 created "2016-06-24" @default.
- W1981019503 creator A5001576573 @default.
- W1981019503 creator A5015229618 @default.
- W1981019503 creator A5024366450 @default.
- W1981019503 creator A5046159238 @default.
- W1981019503 creator A5050787140 @default.
- W1981019503 date "1993-01-01" @default.
- W1981019503 modified "2023-10-18" @default.
- W1981019503 title "EVIDENCE THAT POLYREACTIVE ANTIBODIES ARE DEPOSITED IN REJECTED DISCORDANT XENOGRAFTS" @default.
- W1981019503 doi "https://doi.org/10.1097/00007890-199301000-00031" @default.
- W1981019503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8420044" @default.
- W1981019503 hasPublicationYear "1993" @default.
- W1981019503 type Work @default.
- W1981019503 sameAs 1981019503 @default.
- W1981019503 citedByCount "42" @default.
- W1981019503 countsByYear W19810195032017 @default.
- W1981019503 countsByYear W19810195032018 @default.
- W1981019503 countsByYear W19810195032023 @default.
- W1981019503 crossrefType "journal-article" @default.
- W1981019503 hasAuthorship W1981019503A5001576573 @default.
- W1981019503 hasAuthorship W1981019503A5015229618 @default.
- W1981019503 hasAuthorship W1981019503A5024366450 @default.
- W1981019503 hasAuthorship W1981019503A5046159238 @default.
- W1981019503 hasAuthorship W1981019503A5050787140 @default.
- W1981019503 hasConcept C134018914 @default.
- W1981019503 hasConcept C141071460 @default.
- W1981019503 hasConcept C147483822 @default.
- W1981019503 hasConcept C153911025 @default.
- W1981019503 hasConcept C159654299 @default.
- W1981019503 hasConcept C203014093 @default.
- W1981019503 hasConcept C2776553844 @default.
- W1981019503 hasConcept C2778442404 @default.
- W1981019503 hasConcept C2779594886 @default.
- W1981019503 hasConcept C2780898057 @default.
- W1981019503 hasConcept C2780931953 @default.
- W1981019503 hasConcept C2911091166 @default.
- W1981019503 hasConcept C542903549 @default.
- W1981019503 hasConcept C71924100 @default.
- W1981019503 hasConcept C74505204 @default.
- W1981019503 hasConcept C86803240 @default.
- W1981019503 hasConceptScore W1981019503C134018914 @default.
- W1981019503 hasConceptScore W1981019503C141071460 @default.
- W1981019503 hasConceptScore W1981019503C147483822 @default.
- W1981019503 hasConceptScore W1981019503C153911025 @default.
- W1981019503 hasConceptScore W1981019503C159654299 @default.
- W1981019503 hasConceptScore W1981019503C203014093 @default.
- W1981019503 hasConceptScore W1981019503C2776553844 @default.
- W1981019503 hasConceptScore W1981019503C2778442404 @default.
- W1981019503 hasConceptScore W1981019503C2779594886 @default.
- W1981019503 hasConceptScore W1981019503C2780898057 @default.
- W1981019503 hasConceptScore W1981019503C2780931953 @default.
- W1981019503 hasConceptScore W1981019503C2911091166 @default.
- W1981019503 hasConceptScore W1981019503C542903549 @default.
- W1981019503 hasConceptScore W1981019503C71924100 @default.
- W1981019503 hasConceptScore W1981019503C74505204 @default.
- W1981019503 hasConceptScore W1981019503C86803240 @default.
- W1981019503 hasIssue "1" @default.
- W1981019503 hasLocation W19810195031 @default.
- W1981019503 hasLocation W19810195032 @default.
- W1981019503 hasOpenAccess W1981019503 @default.
- W1981019503 hasPrimaryLocation W19810195031 @default.
- W1981019503 hasRelatedWork W1908561193 @default.
- W1981019503 hasRelatedWork W1973692620 @default.
- W1981019503 hasRelatedWork W1981019503 @default.
- W1981019503 hasRelatedWork W2015480977 @default.
- W1981019503 hasRelatedWork W2037509311 @default.
- W1981019503 hasRelatedWork W2040191638 @default.
- W1981019503 hasRelatedWork W2068369019 @default.
- W1981019503 hasRelatedWork W2071136098 @default.
- W1981019503 hasRelatedWork W2088370636 @default.
- W1981019503 hasRelatedWork W2110230931 @default.
- W1981019503 hasVolume "55" @default.
- W1981019503 isParatext "false" @default.
- W1981019503 isRetracted "false" @default.
- W1981019503 magId "1981019503" @default.
- W1981019503 workType "article" @default.